Evidence map›Paper›PMID 31817608›Full record

ArticleInternational journal of molecular sciences2019

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.

Mateja Sborchia, Hector C Keun, David H Phillips, Volker M Arlt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Chinese herbal medicines · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mateja SborchiaDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London SE1 9NH, UK.
Hector C KeunDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK.ORCID 0000-0001-7358-8851
David H PhillipsDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London SE1 9NH, UK.ORCID 0000-0001-8509-3485
Volker M ArltDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London SE1 9NH, UK.ORCID 0000-0003-4314-9318
King's College London · GBImperial College London · GB

Funding

Cancer Research UK C313/A14329MRC-PHE Centre for Environmental and Health N/A
6 · The paper itself

Abstract

Exposure to aristolochic acid (AA) is linked to kidney disease and urothelial cancer in humans. The major carcinogenic component of the AA plant extract is aristolochic acid I (AAI). The tumour suppressor p53 is frequently mutated in AA-induced tumours. We previously showed that p53 protects from AAI-induced renal proximal tubular injury, but the underlying mechanism(s) involved remain to be further explored. In the present study, we investigated the impact of p53 on AAI-induced gene expression by treating

Indexed as

AnimalsAristolochic AcidsGenotypeKidneyMaleMiceProteomicsSignal TransductionTumor Suppressor Protein p53aristolochic acid IAristolochic AcidsTumor Suppressor Protein p53aristolochic acid Icarcinogen metabolismgene expressionmicroarraymouse modelstumour suppressor p53

Identifiers

PMID31817608
PMCPMC6940885
OpenAlexW2993344190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.