ArticleInternational journal of molecular sciences2019
Structure-Based Redesign of a Self-Sufficient Flavin-Containing Monooxygenase towards Indigo Production.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Tryptophanase Mining and Characterization toward the Biological Production of Indole Derivatives.ACS omega · 2026Article
- Greening the Production of Indigo Blue Exploiting Light and a Recombinant Synechocystis sp. PCC6803 Strain Expressing the Enzyme mFMO.Microbial biotechnology · 2025Article
- Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases.Molecules (Basel, Switzerland) · 2024Article
- Characterization of a novel monooxygenase originating from a deep-sea sediment metagenomic library.Applied microbiology and biotechnology · 2023Article
- Increased Thermostability of an Engineered Flavin-Containing Monooxygenase to Remediate Trimethylamine in Fish Protein Hydrolysates.Applied and environmental microbiology · 2023Article
- Production of indigo by recombinant bacteria.Bioresources and bioprocessing · 2023Review
- Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis.International journal of molecular sciences · 2022Article
- Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin.Bioresources and bioprocessing · 2022Article
- Biocatalysis: "A Jack of all Trades..."International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Indigo is currently produced by a century-old petrochemical-based process, therefore it is highly attractive to develop a more environmentally benign and efficient biotechnological process to produce this timeless dye. Flavin-containing monooxygenases (FMOs) are able to oxidize a wide variety of substrates. In this paper we show that the bacterial mFMO can be adapted to improve its ability to convert indole into indigo. The improvement was achieved by a combination of computational and structure-inspired enzyme redesign. We showed that the thermostability and the
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Registered trials
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