Evidence map›Paper›PMID 31817495›Full record

ArticleCancers2019

Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia.

Antonella Padella, Giorgia Simonetti, Giulia Paciello, George Giotopoulos, Carmen Baldazzi, Simona Righi, Martina Ghetti, Anna Stengel, Viviana Guadagnuolo, Rossella De Tommaso and 17 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. The Fusion Genes and Their Relation with Genetic Variants in Egyptian AML Patients.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Enhancer Hijacking Drives OncogenicCancer discovery · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 4 countries.

Antonella PadellaDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Giorgia SimonettiIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
Giulia PacielloDepartment of Control and Computer Engineering DAUIN, Politecnico di Torino, 10129 Turin, Italy.
George GiotopoulosWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK.
Carmen BaldazziInstitute of Hematology "L. and A. Seràgnoli", Sant'Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
Simona RighiDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Martina GhettiIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
Anna StengelMLL-Munich Leukemia Laboratory, 81377 Munich, Germany.
Viviana GuadagnuoloDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Rossella De TommasoDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Cristina PapayannidisDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Valentina RobustelliDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Eugenia FranchiniIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
Andrea Ghelli Luserna di RoràIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
Anna FerrariIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
Maria Chiara FontanaDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Samantha BrunoDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Emanuela OttavianiDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Simona SoveriniDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Clelia Tiziana StorlazziDepartment of Biology, University of Bari Aldo Moro, 70125 Bari, Italy.
Claudia HaferlachMLL-Munich Leukemia Laboratory, 81377 Munich, Germany.
Elena SabattiniDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Nicoletta TestoniDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40138 Bologna, Italy.
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Brian J P HuntlyWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK.
Elisa FicarraDepartment of Control and Computer Engineering DAUIN, Politecnico di Torino, 10129 Turin, Italy.
Giovanni MartinelliIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy.
University of Bologna · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITMunich Leukemia Laboratory (Germany) · DEPolitecnico di Torino · ITWellcome/MRC Cambridge Stem Cell Institute · GBIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITSt. Jude Children's Research Hospital · USUniversity of Bari Aldo Moro · IT

Funding

Cancer Research UK 25508Medical Research Council MC_PC_12009Medical Research Council MR/R009708/1
6 · The paper itself

Abstract

Approximately 18% of acute myeloid leukemia (AML) cases express a fusion transcript. However, few fusions are recurrent across AML and the identification of these rare chimeras is of interest to characterize AML patients. Here, we studied the transcriptome of 8 adult AML patients with poorly described chromosomal translocation(s), with the aim of identifying novel and rare fusion transcripts. We integrated RNA-sequencing data with multiple approaches including computational analysis, Sanger sequencing, fluorescence in situ hybridization and in vitro studies to assess the oncogenic potential of the

Indexed as

acute myeloid leukemiarare fusion genesZEB2-BCL11B

Identifiers

PMID31817495
PMCPMC6966504
OpenAlexW2993442296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.