Evidence map›Paper›PMID 31817371›Full record

ArticleViruses2019

Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals.

Stephane Pronost, Christine Fortier, Christel Marcillaud-Pitel, Jackie Tapprest, Marc Foursin, Bertrand Saunier, Pierre-Hugues Pitel, Romain Paillot, Erika S Hue

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Stephane PronostLABÉO Frank Duncombe, 14280 Saint-Contest, France.
Christine FortierLABÉO Frank Duncombe, 14280 Saint-Contest, France.
Christel Marcillaud-PitelRESPE, 14280 Saint-Contest, France.
Jackie TapprestLaboratory for Animal Health in Normandy, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14430 Goustranville, France.
Marc FoursinClinique équine de la Boisrie, 61500 Chailloué, France.
Bertrand SaunierStructural Virology Unit-CNRS UMR 3569, Institut Pasteur, 75015 Paris, France.
Pierre-Hugues PitelLABÉO Frank Duncombe, 14280 Saint-Contest, France.
Romain PaillotLABÉO Frank Duncombe, 14280 Saint-Contest, France.ORCID 0000-0003-3081-2037
Erika S HueLABÉO Frank Duncombe, 14280 Saint-Contest, France.ORCID 0000-0001-6930-3606
Normandie Université · FRCentre National de la Recherche Scientifique · FRClinique de l'Yvette · FRDépartement Santé Animale · FRLabéo · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses-and dogs in some instances-and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world's human population, causing an epidemic of liver cirrhosis and cancer. EqHV also chronically infects the liver of horses, but does not appear to cause serious liver damages. Previous studies have been looking to identify route(s) of EqHV transmission to and between horses. (2) Methods: In this retrospective study, we sought to evaluate the prevalence of vertical transmission taking place in utero with measuring by quantitative RT-PCR the amounts of EqHV genome in samples from 394 dead foals or fetuses, paired with the allantochorion whenever available. (3) Results: Detection of EqHV in three foals most likely resulted from a vertical transmission from the mares to the fetuses, consistent with the in utero transmission hypothesis. In support of this observation, the presence of EqHV genome was found for the first time in two of the allantochorions. (4) Conclusions: As seemingly benign viruses could turn deadly (e.g., Zika flavivirus) and EqHV happens to have infected a significant proportion of the world's horse herds, EqHV infectious cycle should be further clarified.

Indexed as

HepacivirusInfectious Disease Transmission, VerticalAnimalsBase SequenceGenes, ViralHepatitis CHorse DiseasesHorsesPhylogenyPrevalenceequine hepacivirusfetuseshorsein utero transmissionnon-primate hepacivirus

Identifiers

PMID31817371
PMCPMC6950541
OpenAlexW2993436727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.