Evidence map›Paper›PMID 31817358›Full record

ArticleMarine drugs2019

In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products.

Concetta Imperatore, Gerardo Della Sala, Marcello Casertano, Paolo Luciano, Anna Aiello, Ilaria Laurenzana, Claudia Piccoli, Marialuisa Menna

Abstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Antiplasmodial Activity ofMolecules (Basel, Switzerland) · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Concetta ImperatoreThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
Gerardo Della SalaLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.ORCID 0000-0001-8957-3259
Marcello CasertanoThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0001-5037-712X
Paolo LucianoThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
Anna AielloThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
Ilaria LaurenzanaLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.ORCID 0000-0001-8289-8325
Claudia PiccoliLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.
Marialuisa MennaThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-4515-3014

Funding

Ministero della Salute CUP E66J12000230001Regione Campania B61G18000470007
6 · The paper itself

Abstract

Several marine natural linear prenylquinones/hydroquinones have been identified as anticancer and antimutagenic agents. Structure-activity relationship studies on natural compounds and their synthetic analogs demonstrated that these effects depend on the length of the prenyl side chain and on the type and position of the substituent groups in the quinone moiety. Aiming to broaden the knowledge of the underlying mechanism of the antiproliferative effect of these prenylated compounds, herein we report the synthesis of two quinones

Indexed as

AdenocarcinomaAntineoplastic AgentsBiological ProductsBone NeoplasmsBreast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalFemaleHumansMCF-7 CellsOsteosarcomaPancreatic NeoplasmsStructure-Activity RelationshipTerpenesAntineoplastic AgentsBiological ProductsTerpenesantiproliferative activitycytostaticG0/G1 cell-cycle arrestmeroterpenoidsorganic synthesissolid tumor cell linesthiazinoquinones

Identifiers

PMID31817358
PMCPMC6950182

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.