ArticlePharmaceutics2019
The Impact of Solvent Selection: Strategies to Guide the Manufacturing of Liposomes Using Microfluidics.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- Impact of solvent choice during microfluidic manufacture on the in vivo performance of liposomal doxorubicin.Drug delivery and translational research · 2026Article
- A Copper-Complexing Lipid Unmasks the Ethanol Hidden Within Liposomes and Highlights the Relevance of Fabrication Method on the Performance of Lipophilic Functional Molecules.Small science · 2026Article
- Liposomal drug delivery for lung cancer therapy: progress, challenges, and future perspectives.Molecular cancer · 2026Review
- Liposomal Formulation of Bioactive Substances fromInternational journal of molecular sciences · 2026Article
- Study on the Mechanisms and Key Influencing Factors of Paclitaxel and Indocyanine Green Co-Loading in Lipid Nanoparticles.Pharmaceutics · 2026Article
- Engineering Biomimetic Nanoparticle Performance Through Fabrication Method Selection: Turbulent Jet Mixing, Microfluidics, and Extrusion.Small methods · 2026Article
- Microfluidic fabrication of pectin-coated liposomes for drug delivery.Drug delivery and translational research · 2025Article
- Machine learning-assisted microfluidic approach for broad-spectrum liposome size control.Journal of pharmaceutical analysis · 2025Article
- OPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility.ACS applied materials & interfaces · 2025Article
- Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis.Asian journal of pharmaceutical sciences · 2024Article
- Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?Pharmaceutics · 2024Article
- Effect of Micromixer Design on Lipid Nanocarriers Manufacturing for the Delivery of Proteins and Nucleic Acids.Pharmaceutics · 2024Article
- Customizable Microfluidic Devices: Progress, Constraints, and Future Advances.Current drug delivery · 2024Review
- The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing.International journal of pharmaceutics: X · 2023Article
- The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method.Foods (Basel, Switzerland) · 2023Article
- Evolution of Vaccines Formulation to Tackle the Challenge of Anti-Microbial Resistant Pathogens.International journal of molecular sciences · 2023Review
- Precise control of liposome size using characteristic time depends on solvent type and membrane properties.Scientific reports · 2023Article
- A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods.Discover nano · 2023Review
- Development of Novel Lipid-Based Formulations for Water-Soluble Vitamin C versus Fat-Soluble Vitamin D3.Bioengineering (Basel, Switzerland) · 2022Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The aim of this work was to assess the impact of solvent selection on the microfluidic production of liposomes. To achieve this, liposomes were manufactured using small-scale and bench-scale microfluidics systems using three aqueous miscible solvents (methanol, ethanol or isopropanol, alone or in combination). Liposomes composed of different lipid compositions were manufactured using these different solvents and characterised to investigate the influence of solvents on liposome attributes. Our studies demonstrate that solvent selection is a key consideration during the microfluidics manufacturing process, not only when considering lipid solubility but also with regard to the resultant liposome critical quality attributes. In general, reducing the polarity of the solvent (from methanol to isopropanol) increased the liposome particle size without impacting liposome short-term stability or release characteristics. Furthermore, solvent combinations such as methanol/isopropanol mixtures can be used to modify solvent polarity and the resultant liposome particle size. However, the impact of solvent choice on the liposome product is also influenced by the liposome formulation; liposomes containing charged lipids tended to show more sensitivity to solvent selection and formulations containing increased concentrations of cholesterol or pegylated-lipids were less influenced by the choice of solvent. Indeed, incorporation of 14 wt% or more of pegylated-lipid was shown to negate the impact of solvent selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.