ArticleNutrients2019
Assessment of Vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Association between Dental and Cardiovascular Diseases: A Systematic Review.Reviews in cardiovascular medicine · 2023Pooled it
- Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis-Antibacterial Effects.Nutrients · 2021Pooled it
- Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association.Nutrients · 2020Pooled it
- Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial.Clinical oral investigations · 2021Trial
- Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique.Colombia medica (Cali, Colombia) · 2020Trial
- Salivary Osteocalcin as Potential Diagnostic Marker of Periodontal Bone Destruction among Smokers.Biomolecules · 2020Trial
- Trial
- miR-511-5p is a potential biomarker of periodontitis and inhibits the inflammatory response via targeting SOST.Odontology · 2026Article
- Assessment of Salivary Osteocalcin Level Among Smokers and Non-Smokers Undergoing Dental Implants: An Observational Study.Journal of pharmacy & bioallied sciences · 2026Article
- The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits.International journal of molecular sciences · 2025Review
- The effect of systemic lycopene supplementation on non-surgical periodontal therapy outcomes: A clinical trial.BDJ open · 2025Article
- Therapeutic Uses of Retinol and Retinoid-Related Antioxidants.Molecules (Basel, Switzerland) · 2025Review
- Evaluation of Serum Vitamin D and C Concentrations in Cats With Gingivostomatitis.Veterinary medicine and science · 2025Article
- Salivary and GCF Vitamin C Levels: Implications for Local and Systemic Periodontal Defense.International journal of dentistry · 2025Article
- The Effect of Vitamin E, Β-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study.Clinical, cosmetic and investigational dentistry · 2025Article
- Association of Salivary Vitamin D and Vitamin C Levels with Dental Caries in Children: A Cross-sectional Study.International journal of clinical pediatric dentistry · 2024Article
- Association Between Nutrients and Cardiovascular Diseases.Current cardiology reviews · 2024Review
- Diagnostic potential of miR-200 family members in gingival crevicular fluid for chronic periodontitis: correlation with clinical parameters and therapeutic implications.BMC oral health · 2023Article
- The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry.Journal of personalized medicine · 2023Review
- Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach.Therapeutic advances in chronic disease · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin C and antioxidants play a crucial role in endothelial function and may be a link for the known interaction of periodontitis and ischemic heart disease (CAD). This pilot study evaluates the association of gingival health, periodontitis, CAD, or both conditions with salivary and serum vitamin C and antioxidant levels. The clinical and periodontal characteristics, serum, and saliva samples were collected from 36 patients with periodontitis, 35 patients with CAD, 36 patients with periodontitis plus CAD, and 36 healthy controls. Levels of vitamin C, antioxidants, and C-reactive protein (hs-CRP) were assessed with a commercially available kit. The median concentrations of salivary and serum vitamin C and antioxidants (α-tocopherol, β-carotene, lutein, and lycopene) were significantly lower in the CAD group (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.