Evidence map›Paper›PMID 31817125›Full record

Observational studyNutrients2019

Reduction of Serum Concentrations and Synergy between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women with Breast Cancer.

Cintia Rosa, Carlos Franca, Sérgio Lanes Vieira, Antônio Carvalho, Antônio Penna, Carla Nogueira, Suzane Lessa, Andrea Ramalho

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Cintia RosaSocial Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Carlos FrancaSocial Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Sérgio Lanes VieiraDepartment of Radiation Oncology, Ingá Radiotherapy Clinic (CRI), Brazilian Institute of Oncology (IBO), Federal University of Rio de Janeiro, Niterói 24.210-470, Brazil.
Antônio CarvalhoDepartment of Radiology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Antônio PennaDepartment of Radiation Oncology, Ingá Radiotherapy Clinic (CRI), Brazilian Institute of Oncology (IBO), Federal University of Rio de Janeiro, Niterói 24.210-470, Brazil.
Carla NogueiraSocial Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Suzane LessaSocial Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Andrea RamalhoSocial Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The procedures used for breast cancer treatment are able to increase the level of oxidative stress and cause depletion of antioxidants.

objectivesTo investigate the relationship between serum concentrations of retinol, β-carotene, and zinc, according to breast cancer staging, considering different treatment modalities prior to radiation therapy and the synergistic action between these micronutrients.

methodsThis is a cross-sectional observational study comprising a cohort of patients with breast cancer which was carried out prior to radiation therapy. Patients were divided into 3 groups: G1 comprised women who had undergone breast-conserving surgery, G2 comprised those who had undergone chemotherapy, and G3 those who had undergone breast-conserving surgery and chemotherapy. Serum concentrations of retinol, β-carotene, and zinc were quantified. Breast cancer staging was based on the TNM (Tumor, Node, Metastasis) classification of malignant tumors, a type of staging tool for different cancers.

resultsA total of 230 patients were assessed. A decrease of the serum concentrations of the micronutrients assessed as the staging level of the disease increased was observed. Surgery alone had a greater negative impact on serum concentrations of retinol. Considering the treatments prior to radiotherapy, patients undergoing surgery alone and chemotherapy associated with surgery had higher percentages of deficiency of β-carotene and retinol. There was a positive correlation between the concentrations of zinc, retinol, and β-carotene, showing a synergy between these micronutrients.

conclusionA significant reduction in the serum concentrations of the assessed micronutrients was observed, according to the increase in breast cancer staging. The synergy between the micronutrients must be considered in order to maximize the benefits and minimize the adverse effects of irradiation to normal cells.

Indexed as

Breast NeoplasmsAgedAntioxidantsbeta CaroteneFemaleHumansMiddle AgedNeoplasm StagingVitamin AZincAntioxidantsbeta CaroteneVitamin AZincantioxidantsbreast cancerchemotherapyconservative surgeryradiotherapytoxicity

Identifiers

PMID31817125
PMCPMC6950526
OpenAlexW2993880575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.