Evidence map›Paper›PMID 31817090›Full record

ReviewCancers2019

Promising Colorectal Cancer Biomarkers for Precision Prevention and Therapy.

Mimmo Turano, Paolo Delrio, Daniela Rega, Francesca Cammarota, Alessia Polverino, Francesca Duraturo, Paola Izzo, Marina De Rosa

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mimmo TuranoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0002-4934-0562
Paolo DelrioColorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo studio e la cura dei tumori, 'Fondazione Giovanni Pascale'-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 80131 Naples, Italy.
Daniela RegaColorectal Surgical Oncology, Abdominal Oncology Department, Istituto Nazionale per lo studio e la cura dei tumori, 'Fondazione Giovanni Pascale'-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 80131 Naples, Italy.
Francesca CammarotaDepartment of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples Federico II, 80131 Naples, Italy.
Alessia PolverinoDepartment of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples Federico II, 80131 Naples, Italy.
Francesca DuraturoDepartment of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples Federico II, 80131 Naples, Italy.
Paola IzzoDepartment of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples Federico II, 80131 Naples, Italy.
Marina De RosaDepartment of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4752-5678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) has been ranked as the third most prevalent cancer worldwide. Indeed, it represents 10.2% of all cancer cases. It is also the second most common cause of cancer mortality, and accounted for about 9.2% of all cancer deaths in 2018. Early detection together with a correct diagnosis and staging remains the most effective clinical strategy in terms of disease recovery. Thanks to advances in diagnostic techniques, and improvements of surgical adjuvant and palliative therapies, the mortality rate of CRC has decreased by more than 20% in the last decade. Cancer biomarkers for the early detection of CRC, its management, treatment and follow-up have contributed to the decrease in CRC mortality. Herein, we provide an overview of molecular biomarkers from tumor tissues and liquid biopsies that are approved for use in the CRC clinical setting for early detection, follow-up, and precision therapy, and of biomarkers that have not yet been officially validated and are, nowadays, under investigation.

Indexed as

cancer preventioncolorectal cancerearly cancer detectionmolecular biomarkersprecision therapy

Identifiers

PMID31817090
PMCPMC6966638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.