Evidence map›Paper›PMID 31817026›Full record

ArticleInternational journal of molecular sciences2019

Combined Treatment with Low-Dose Ionizing Radiation and Ketamine Induces Adverse Changes in CA1 Neuronal Structure in Male Murine Hippocampi.

Daniela Hladik, Sonja Buratovic, Christine Von Toerne, Omid Azimzadeh, Prabal Subedi, Jos Philipp, Stefanie Winkler, Annette Feuchtinger, Elenore Samson, Stefanie M Hauck and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Daniela HladikInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Sonja BuratovicDepartment of Environmental Toxicology, University Uppsala, 75236 Uppsala, Sweden.
Christine Von ToerneResearch Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 80939 Munich, Germany.ORCID 0000-0002-4132-4322
Omid AzimzadehInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Prabal SubediInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Jos PhilippInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.ORCID 0000-0002-5002-767X
Stefanie WinklerInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Annette FeuchtingerResearch Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Elenore SamsonResearch Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 80939 Munich, Germany.ORCID 0000-0002-1630-6827
Bo StenerlöwDepartment of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden.
Per ErikssonDepartment of Environmental Toxicology, University Uppsala, 75236 Uppsala, Sweden.
Michael J AtkinsonInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.
Soile TapioInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH (HMGU), 85764 Neuherberg, Germany.ORCID 0000-0001-9860-3683
Helmholtz Zentrum München · DEUppsala University · SE

Funding

Bundesministerium für Bildung und Forschung 02NUK045CH2020 Euratom No 662287Strålsäkerhetsmyndigheten x
6 · The paper itself

Abstract

In children, ketamine sedation is often used during radiological procedures. Combined exposure of ketamine and radiation at doses that alone did not affect learning and memory induced permanent cognitive impairment in mice. The aim of this study was to elucidate the mechanism behind this adverse outcome. Neonatal male NMRI mice were administered ketamine (7.5 mg kg

Indexed as

Radiation, IonizingAnimalsAnimals, NewbornCA1 Region, HippocampalCell ShapeCytoskeletonKetamineMaleMiceNeuronal PlasticityNeuronsProteomeKetamineProteomeBDNFCA1 neuronsdendrite abnormalityGolgi staininghippocampusirradiationproteomics

Identifiers

PMID31817026
PMCPMC6929167
OpenAlexW2991869130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.