Evidence map›Paper›PMID 31817006›Full record

ArticleSensors (Basel, Switzerland)2019

A Novel Framework with High Diagnostic Sensitivity for Lung Cancer Detection by Electronic Nose.

Binchun Lu, Lidan Fu, Bo Nie, Zhiyun Peng, Hongying Liu

Abstract readMulticenter Study
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Binchun LuChongqing University-University of Cincinnati Joint Co-op Institute, Chongqing University, Chongqing 400030, China.
Lidan FuChongqing University-University of Cincinnati Joint Co-op Institute, Chongqing University, Chongqing 400030, China.
Bo NieKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Zhiyun PengState Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing University, Chongqing 400030, China.
Hongying LiuKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.

Funding

National Natural Science Foundation of China 81671850
6 · The paper itself

Abstract

The electronic nose (e-nose) system is a newly developing detection technology for its advantages of non-invasiveness, simple operation, and low cost. However, lung cancer screening through e-nose requires effective pattern recognition frameworks. Existing frameworks rely heavily on hand-crafted features and have relatively low diagnostic sensitivity. To handle these problems, gated recurrent unit based autoencoder (GRU-AE) is adopted to automatically extract features from temporal and high-dimensional e-nose data. Moreover, we propose a novel margin and sensitivity based ordering ensemble pruning (MSEP) model for effective classification. The proposed heuristic model aims to reduce missed diagnosis rate of lung cancer patients while maintaining a high rate of overall identification. In the experiments, five state-of-the-art classification models and two popular dimensionality reduction methods were involved for comparison to demonstrate the validity of the proposed GRU-AE-MSEP framework, through 214 collected breath samples measured by e-nose. Experimental results indicated that the proposed intelligent framework achieved high sensitivity of 94.22%, accuracy of 93.55%, and specificity of 92.80%, thereby providing a new practical means for wide disease screening by e-nose in medical scenarios.

Indexed as

Electronic NosePattern Recognition, AutomatedAgedAlgorithmsBreath TestsCase-Control StudiesDiagnosis, Computer-AssistedEarly Detection of CancerFemaleHumansLung NeoplasmsMaleMiddle AgedMissed DiagnosisModels, StatisticalPulmonary Disease, Chronic ObstructiveVolatile Organic Compoundsautoencoderelectronic noseensemble pruninglung cancervolatile organic compounds

Identifiers

PMID31817006
PMCPMC6928832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.