Evidence map›Paper›PMID 31816981›Full record

SynthesisNutrients2019

A Systematic Review and Meta-Analysis on the Effects of Probiotic Species on Iron Absorption and Iron Status.

Susan C Vonderheid, Lisa Tussing-Humphreys, Chang Park, Heather Pauls, Nefertiti OjiNjideka Hemphill, Bazil LaBomascus, Andrew McLeod, Mary Dawn Koenig

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06521879 (Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement), which is not on this map. Cited by 51 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 8 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06521879 nacompletednot on this mapstarted 2022, after this paper: background citation

Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement

TypeinterventionalSponsorAntalya Training and Research HospitalRan2022 to 2023Enrolled295ConditionsIron Deficiency Anemia Treatment, Iron Deficiency AnemiaArmsLactobacillus plantarum 299v probiotic support
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 8 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  9. Trial
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  14. Heat-KilledNutrients · 2022
    Trial
  15. Trial
  16. The Effect ofNutrients · 2020
    Trial
  17. Review
  18. Review
  19. Nutrients · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Susan C VonderheidCollege of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA.
Lisa Tussing-HumphreysDepartment of Medicine and Cancer Center, University of Illinois at Chicago, Chicago, IL 60608, USA.
Chang ParkCollege of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA.
Heather PaulsCollege of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA.
Nefertiti OjiNjideka HemphillDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
Bazil LaBomascusDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
Andrew McLeodDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
Mary Dawn KoenigCollege of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA.
University of Illinois Chicago · US

Funding

Center for Health Equity Research (CHER) Chicago #U54MD012523; Subaward #088917CSRD VA 1Robert Wood Johnson Foundation 72117
6 · The paper itself

Abstract

backgroundStrategies to prevent iron deficiency anemia (IDA) have varying effectiveness. The purpose of this systematic review of the literature and meta-analysis was to examine the effects of probiotics on iron absorption and iron status-related markers in humans.

methodsWe followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) reporting guidelines. Relevant articles were identified from Embase, Pubmed, Scopus, and CINAHL from inception to February, 2019. We conducted a meta-analysis for eight studies examining the effect of the probiotic

resultsFifteen studies reported in 12 articles were identified (N = 950). Our meta-analysis of eight studies using a random-effects model demonstrated a significant increase in iron absorption following administration of the probiotic

conclusions

Indexed as

Anemia, Iron-DeficiencyHumansIronLactiplantibacillus plantarumProbioticsIronhumaniron absorptioniron statusprobiotic

Identifiers

PMID31816981
PMCPMC6949908
OpenAlexW2994292128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.