Evidence map›Paper›PMID 31816953›Full record

ArticleInternational journal of molecular sciences2019

A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration.

Dasiel O Borroto-Escuela, Karolina Wydra, Wilber Romero-Fernandez, Zilong Zhou, Malgorzata Frankowska, Malgorzata Filip, Kjell Fuxe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Guanosine modulates KPflugers Archiv : European journal of physiology · 2022
    Article
  4. Review
  5. Allosteric Interactions between Adenosine AInternational journal of molecular sciences · 2021
    Review
  6. Adenosine ACells · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Dasiel O Borroto-EscuelaDepartment of Neuroscience, Karolinska Institutet, 16175 Stockholm, Sweden.ORCID 0000-0002-5736-373X
Karolina WydraDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Kraków, Poland.
Wilber Romero-FernandezDepartment of Neuroscience, Karolinska Institutet, 16175 Stockholm, Sweden.
Zilong ZhouDepartment of Neuroscience, Karolinska Institutet, 16175 Stockholm, Sweden.
Malgorzata FrankowskaDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-6646-6140
Malgorzata FilipDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Kraków, Poland.
Kjell FuxeDepartment of Neuroscience, Karolinska Institutet, 16175 Stockholm, Sweden.
Maj Institute of Pharmacology · PLKarolinska Institutet · SENortheast Normal University · CNUniversity of Urbino · ITUppsala University · SE

Funding

Hjärnfonden F02018-0286Hjärnfonden F02019-0296Parkinson Fonden 2018-KFVetenskapsrådet 62X-00715-50-3
6 · The paper itself

Abstract

It was previously demonstrated that rat adenosine A2AR transmembrane V peptide administration into the nucleus accumbens enhances cocaine self-administration through disruption of the A2AR-dopamine (D2R) heteroreceptor complex of this region. Unlike human A2AR transmembrane 4 (TM4) and 5 (TM5), A2AR TM2 did not interfere with the formation of the A2AR-D2R heteroreceptor complex in cellular models using BRET

Indexed as

Self AdministrationAdenosineAdenosine A2 Receptor AgonistsAnimalsCell MembraneCocaineMaleMicroinjectionsModels, MolecularNucleus AccumbensPeptidesPhenethylaminesProtein MultimerizationQuinpiroleRacloprideRats, Sprague-Dawley2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineAdenosineAdenosine A2 Receptor AgonistsCocainePeptidesPhenethylaminesQuinpiroleRacloprideReceptor, Adenosine A2AReceptors, Dopamine D2adenosine A2A receptorallosteric receptor–receptor interactionscocaine use disorderdopamine D2 receptorheteroreceptor complexeshomoreceptor complexessmall interfering peptides: G protein-coupled receptors

Identifiers

PMID31816953
PMCPMC6928905
OpenAlexW2993741080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.