Evidence map›Paper›PMID 31816942›Full record

ArticleToxins2019

Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation.

Jaime Ribeiro-Filho, Fagner Carvalho Leite, Andrea Surrage Calheiros, Alan de Brito Carneiro, Juliana Alves Azeredo, Edson Fernandes de Assis, Celidarque da Silva Dias, Márcia Regina Piuvezam, Patrícia T Bozza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jaime Ribeiro-FilhoLaboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil.ORCID 0000-0003-3126-6509
Fagner Carvalho LeiteLaboratório de Imunofarmacologia, Departamento de Fisiologia e Patologia, UFPB, João Pessoa 58051-900, Brazil.
Andrea Surrage CalheirosLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Alan de Brito CarneiroLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Juliana Alves AzeredoLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Edson Fernandes de AssisLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Celidarque da Silva DiasLaboratório de Fitoquímica, Departamento de Ciências Farmacêuticas, UFPB, João Pessoa 58051-900, Brazil.
Márcia Regina PiuvezamLaboratório de Imunofarmacologia, Departamento de Fisiologia e Patologia, UFPB, João Pessoa 58051-900, Brazil.
Patrícia T BozzaLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curine is a bisbenzylisoquinoline alkaloid (BBA) with anti-allergic, analgesic, and anti-inflammatory properties. Previous studies have demonstrated that this alkaloid is orally active at non-toxic doses. However, the mechanisms underlying its anti-inflammatory effects remain to be elucidated. This work aimed to investigate the effects of curine on macrophage activation and neutrophil recruitment. Using a murine model of lipopolysaccharide (LPS)-induced pleurisy, we demonstrated that curine significantly inhibited the recruitment of neutrophils in association with the inhibition of cytokines tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, monocyte chemotactic protein (CCL2/MCP-1) as well as leukotriene B

Indexed as

AnimalsAnti-Inflammatory AgentsCalciumCytokinesDisease Models, AnimalInflammationIsoquinolinesLipopolysaccharidesMacrophage ActivationMacrophages, PeritonealMaleMice, Inbred C57BLNeutrophil InfiltrationNitric OxideNitric Oxide Synthase Type IIAnti-Inflammatory AgentsCalciumcurineCytokinesIsoquinolinesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINos2 protein, mousealkaloidCurinelipopolysaccharidemacrophageneutrophil

Identifiers

PMID31816942
PMCPMC6950719
OpenAlexW2994014096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.