Evidence map›Paper›PMID 31816919›Full record

ReviewNanomaterials (Basel, Switzerland)2019

Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis.

Shiue-Luen Chen, Chong-You Chen, Jason Chia-Hsun Hsieh, Zih-Yu Yu, Sheng-Jen Cheng, Kuan Yu Hsieh, Jia-Wei Yang, Priyank V Kumar, Shien-Fong Lin, Guan-Yu Chen

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shiue-Luen ChenDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.
Chong-You ChenDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-9824-1202
Jason Chia-Hsun HsiehDivision of Haematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital (Linkou), Taoyuan 333, Taiwan.ORCID 0000-0002-5547-409X
Zih-Yu YuDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.
Sheng-Jen ChengDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.
Kuan Yu HsiehDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0003-3021-7684
Jia-Wei YangDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.
Priyank V KumarSchool of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Shien-Fong LinDepartment of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0003-1270-3961
Guan-Yu ChenInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-3443-7943
National Yang Ming Chiao Tung University · TWChang Gung Memorial Hospital · TWUNSW Sydney · AU

Funding

Ministry of Science and Technology, Taiwan MOST 107-2622-E-009-023-CC1, MOST-107-EPA-F-007-002, MOST-108-2636-E-009-007-Ministry of Science and Technology, Taiwan MOST 108-2633-B-009-001.National Chiao Tung University 108W204, 108W211National Health Research Institutes Taiwan NHRI-EX108-10714ECthe Higher Education Sprout Project of the National Chiao Tung University and the Ministry of Education, Taiwan none
6 · The paper itself

Abstract

Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology.

Indexed as

circulating tumor cellscirculating tumor DNAexosomegraphene oxideliquid biopsy

Identifiers

PMID31816919
PMCPMC6956293
OpenAlexW2993704477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.