Evidence map›Paper›PMID 31816898›Full record

ArticlePharmaceutics2019

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography.

Andrew V Healy, Evert Fuenmayor, Patrick Doran, Luke M Geever, Clement L Higginbotham, John G Lyons

Abstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. 3D-printed dosage forms for oral administration: a review.Drug delivery and translational research · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew V HealyMaterials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.ORCID 0000-0002-9466-5964
Evert FuenmayorMaterials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.
Patrick DoranApplied Polymer Technologies Gateway, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.
Luke M GeeverMaterials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.
Clement L HigginbothamMaterials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.
John G LyonsFaculty of Engineering and Informatics, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland.ORCID 0000-0003-1998-070X

Funding

Enterprise Ireland TG-2017-0114Science Foundation Ireland 16/RC/3918
6 · The paper itself

Abstract

The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on a monomer mixture that, to date, has not been reported in the literature, with paracetamol and aspirin selected as model drugs. In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator. The fabrication of 28 dosages in one print process was possible and the printed dosage forms were characterized for their drug release properties. It was established that both drugs displayed a sustained release over a 24-h period. The physical properties were also investigated, illustrating that SLA affords accurate printing of dosages with some statistically significant differences observed from the targeted dimensional range, indicating an area for future process improvement. The work presented in this paper demonstrates that SLA has the ability to produce small, individualized batches which may be tailored to meet patients' specific needs or provide for the localized production of pharmaceutical dosage forms.

Indexed as

3D printed oral dosage formsadditive manufacturingaspirin (acetylsalicylic acid)drug deliveryparacetamol (acetaminophen)personalized medicinephotopolymerizationstereolithographysustained drug release tabletsthree-dimensional printing

Identifiers

PMID31816898
PMCPMC6955879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.