Evidence map›Paper›PMID 31816875›Full record

Trial reportNutrients2019

An Isocaloric Nordic Diet Modulates

Stine M Ulven, Kirsten B Holven, Amanda Rundblad, Mari C W Myhrstad, Lena Leder, Ingrid Dahlman, Vanessa D de Mello, Ursula Schwab, Carsten Carlberg, Jussi Pihlajamäki and 15 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 6 countries.

Stine M UlvenDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Kirsten B HolvenDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.ORCID 0000-0002-8674-9703
Amanda RundbladDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Mari C W MyhrstadDepartment of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, 0130 Oslo, Norway.
Lena LederMills AS, Sofienberggt. 19, 0558 Oslo, Norway.
Ingrid DahlmanDepartment of Medicine (H7), Karolinska Institute, 17176 Stockholm, Sweden.
Vanessa D de MelloSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0003-3414-6983
Ursula SchwabSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
Carsten CarlbergInstitute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0003-2633-0684
Jussi PihlajamäkiSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
Kjeld HermansenDepartment of Endocrinology and Internal Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, 8200 Aarhus, Denmark.
Lars O DragstedDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-0609-6317
Ingibjörg GunnarsdottirUnit for Nutrition Research, University of Iceland and Landspitali-The National University Hospital of Iceland, 101 Reykjavík, Iceland.
Lieselotte CloetensBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, 221 00 Lund, Sweden.ORCID 0000-0001-5324-4410
Björn ÅkessonBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, 221 00 Lund, Sweden.
Fredrik RosqvistDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 22 Uppsala, Sweden.
Janne HukkanenInstitute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Medical Research Center, Oulu University Hospital, 90220 Oulu, Finland.
Karl-Heinz HerzigInstitute of Biomedicine, Biocenter of Oulu, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, 90220 Oulu, Finland.ORCID 0000-0003-4460-2604
Markku J SavolainenInstitute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Medical Research Center, Oulu University Hospital, 90220 Oulu, Finland.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 22 Uppsala, Sweden.
Inga ThorsdottirUnit for Nutrition Research, University of Iceland and Landspitali-The National University Hospital of Iceland, 101 Reykjavík, Iceland.
Kaisa S PoutanenSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
Peter ArnerDepartment of Medicine (H7), Karolinska Institute, 17176 Stockholm, Sweden.
Matti UusitupaSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0001-6052-2001
Marjukka KolehmainenSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.
University of Eastern Finland · FIKarolinska Institutet · SELund University · SEOulu University Hospital · FIUniversity of Iceland · ISUniversity of Oslo · NOUppsala University · SEAarhus University Hospital · DKMills (Norway) · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NOPoznan University of Medical Sciences · PLUniversity of Copenhagen · DK

Funding

NordForsk 070014
6 · The paper itself

Abstract

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A

Indexed as

Diet TherapyAdultFemaleGene Expression RegulationHumansLeukocytes, MononuclearMaleMetabolic SyndromeMiddle AgedProto-Oncogene MasReceptors, Tumor Necrosis Factor, Type ITranscription Factor RelATranscriptomeMAS1 protein, humanProto-Oncogene MasReceptors, Tumor Necrosis Factor, Type IRELA protein, humanTNFRSF1A protein, humanTranscription Factor RelAgene expressioninflammationmetabolic syndromeperipheral blood mononuclear cellsrandomized controlled dietary intervention

Identifiers

PMID31816875
PMCPMC6950764
OpenAlexW2993050585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.