ArticleMolecular genetics & genomic medicine2020
Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic Analysis ofAnimals : an open access journal from MDPI · 2024Article
- Heat shock protein 70 gene polymorphisms in Iranian patients with Multiple sclerosis.American journal of clinical and experimental immunology · 2024Article
- A Polymorphism in the Gene Encoding Heat Shock Factor 1 (Life (Basel, Switzerland) · 2022Article
- CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis.Diabetology & metabolic syndrome · 2022Article
- High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.BioMed research international · 2022Article
- Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.Molecular genetics & genomic medicine · 2020Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
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Abstract
backgroundType 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat-shock proteins (HSPs). Current study assessed the frequency and association of HSP70-hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis.
methodsThis polymorphism was selected through bioinformatics analyses and identified by PCR-RFLP method.
resultsBioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association.
conclusionsHSP70-hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress-dependent and independent manners.
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