Evidence map›Paper›PMID 31816634›Full record

ArticleThe Journal of experimental medicine2020

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis.

Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Shenghua Zhang, Rui Wu, Zheng Zhang and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 217 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. The hidden players: LncRNA-Encoded micropeptides in cancer hallmarks.Cellular and molecular life sciences : CMLS · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. RiboMicrobe: An Integrated Translatome Atlas for Microorganism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yirong Wang *Department of Genetics, Medical College of Soochow University, Suzhou, China.
Siqi Wu *Department of Genetics, Medical College of Soochow University, Suzhou, China.
Xun Zhu *Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Liyuan Zhang *Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jieqiong DengDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Fang LiDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Binbin GuoDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Shenghua ZhangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Rui WuDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Zheng ZhangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Kexin WangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Jiachun LuThe State Key Lab of Respiratory Disease, The First Affiliated Hospital, The School of Public Health, Guangzhou Medical University, Guangzhou, China.
Yifeng ZhouDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Soochow University · CNFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) with the most aggressive phenotype and poor overall survival. Using bioinformatics tools, we identified LINC00908 encoding a 60-aa polypeptide and differentially expressed in TNBC tissues. We named this endogenously expressed polypeptide ASRPS (a small regulatory peptide of STAT3). ASRPS expression was down-regulated in TNBCs and associated with poor overall survival. We showed that LINC00908 was directly regulated by ERα, which was responsible for the differential down-regulation of LINC00908 in TNBCs. ASRPS directly bound to STAT3 through the coiled coil domain (CCD) and down-regulated STAT3 phosphorylation, which led to reduced expression of VEGF. In human endothelial cells, a mouse xenograft breast cancer model, and a mouse spontaneous BC model, ASRPS expression reduced angiogenesis. In a mouse xenograft breast cancer model, down-regulation of ASRPS promoted tumor growth, and ASRPS acted as an antitumor peptide. We presented strong evidence that LINC00908-encoded polypeptide ASRPS represented a TNBC-specific target for treatment.

Indexed as

Amino Acid SequenceAnimalsBase SequenceCell Line, TumorCell ProliferationDown-RegulationEndothelial CellsFemaleGene Expression Regulation, NeoplasticHEK293 CellsHumansMCF-7 CellsMice, Inbred BALB CMice, Inbred C57BLMice, NudeNeovascularization, PathologicPeptidesRNA, Long NoncodingSTAT3 Transcription Factor

Identifiers

PMID31816634
PMCPMC7062514
OpenAlexW2991798444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.