ArticlePediatric research2020
Fungal cutaneous microbiome and host determinants in preterm and term neonates.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Fungal DNA profiles across maternal and neonatal biological sites: findings from an exploratory pilot study.Frontiers in microbiology · 2026Article
- Congenital Sepsis withMicroorganisms · 2024Review
- Neonatal Microbiome: Is it Still Beneficial?Endocrine, metabolic & immune disorders drug targets · 2024Article
- It's time to shed some light on the importance of fungi in neonatal intensive care units: what do we know about the neonatal mycobiome?Frontiers in microbiology · 2024Review
- The Role of Yeasts in Human Health: A Review.Life (Basel, Switzerland) · 2023Review
- The dynamic balance of the skin microbiome across the lifespan.Biochemical Society transactions · 2023Review
- Forgotten fungi: the importance of the skin mycobiome.Current opinion in microbiology · 2022Review
- Neonatal sepsis and the skin microbiome.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Early life host-microbe interactions in skin.Cell host & microbe · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neonatal cutaneous mycobiome has not been characterized in preterm infants. Invasive fungal infections in preterm neonates are associated with high mortality. The immaturity of the preterm skin predisposes neonates to invasive infection by skin colonizers. We report the clinical and host determinants that influence the skin mycobiome.
methodsSkin swabs from the antecubital fossa, forehead, and gluteal region of 15 preterm and 15 term neonates were obtained during the first 5 weeks of life. The mycobiome was sequenced using the conserved pan-fungal ITS2 region. Blood samples were used to genotype immune modulating genes. Clinical metadata was collected to determine the clinical predictors of the abundance and diversity of the skin mycobiome.
resultsThe neonatal mycobiome is characterized by few taxa. Alpha diversity of the mycobiome is influenced by antibiotic exposure, the forehead body site, and the neonatal intensive care unit (NICU) environment. Beta diversity varies with mode of delivery, diet, and body site. The host determinants of the cutaneous microbiome include single-nucleotide polymorphisms in TLR4, NLRP3,CARD8, and NOD2.
conclusionThe neonatal cutaneous mycobiome is composed of few genera and is influenced by clinical factors and host genetics, the understanding of which will inform preventive strategies against invasive fungal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.