Evidence map›Paper›PMID 31816571›Full record

ReviewCurrent opinion in neurobiology2020

The gut microbiome: an unexpected player in cancer immunity.

Scott N Peterson, Linda M Bradley, Ze'ev A Ronai

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Updates on Group BMicroorganisms · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Gut Microbiota in Lung Cancer: Where Do We Stand?International journal of molecular sciences · 2021
    Review
  17. Review
  18. Dairy associations for the targeted control of opportunistic Candida.World journal of microbiology & biotechnology · 2021
    Article
  19. Review
  20. The Role of Gut Microbiota in Tumor Immunotherapy.Journal of immunology research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Scott N PetersonSanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines, La Jolla, CA, 92037, United States.
Linda M BradleySanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines, La Jolla, CA, 92037, United States.
Ze'ev A RonaiSanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines, La Jolla, CA, 92037, United States. Electronic address: ronai@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute · USDiscovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Tumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI OSTERMAN, ANDREI L · 2009 to 2020
$19.1M
Rewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA197465 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZEEV A. · 2016 to 2022
$7.9M
Linking the microbiome and immune-checkpoint in melanoma by RNF5R01CA216187 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BRADLEY, LINDA MAC PHERSON · 2017 to 2021
$3.0M
NCI NIH HHS P01 CA128814NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA216187NCI NIH HHS R35 CA197465
6 · The paper itself

Abstract

Numerous independent studies link gut microbiota composition and disease and imply a causal role of select commensal microbes in disease etiology. In the gut, commensal microbiota or pathobionts secrete metabolites that underlie pathological conditions, often impacting proximal tissues and gaining access to the bloodstream. Here we focus on extrinsic and intrinsic factors affecting composition of gut microbiota and their impact on the immune system, as key drivers of anti-tumor immunity. In discussing exciting advances relevant to microbiome-tumor interaction, we note existing knowledge gaps that need to be filled to advance basic and clinical research initiatives.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaNeoplasmsHumans

Identifiers

PMID31816571
PMCPMC7274858
OpenAlexW2993251675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.