ArticleDrug and alcohol dependence2020
Multimodal assessment of sleep in men and women during treatment for opioid use disorder.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep Health Among Adults in Outpatient Opioid Use Disorder Treatment: A Systematic Review.Journal of psychosocial nursing and mental health services · 2024Pooled it
- Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study.Addiction (Abingdon, England) · 2026Article
- Acute and persistent sex-dependent disruptions of sleep-wake architecture induced by fentanyl self-administration in mice.Neuropharmacology · 2026Article
- Sleep and Substance Use: Exploring Reciprocal Impacts and Therapeutic Approaches.Current psychiatry reports · 2025Review
- Rest-Activity Rhythms, Their Modulators, and Brain-Clinical Correlates in Opioid Use Disorder.JAMA network open · 2025Article
- Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review.Current addiction reports · 2024Article
- Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder.Frontiers in psychiatry · 2024Article
- Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment.Frontiers in neurology · 2024Article
- Promoting sleep health to mitigate the risk of nonmedical opioid use and opioid-related adverse events.Sleep · 2023Article
- Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice.Frontiers in pharmacology · 2023Article
- Wireless electroencephalography (EEG) to monitor sleep among patients being withdrawn from opioids: Evidence of feasibility and utility.Experimental and clinical psychopharmacology · 2022Article
- Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.Clinics in chest medicine · 2022Review
- Poor Sleep Quality and Other Risk Factors for Unemployment Among Patients on Opioid Agonist Treatment.Substance abuse : research and treatment · 2022Article
- Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain.Pain medicine (Malden, Mass.) · 2021Article
- Addiction treatment in the postpartum period: an opportunity for evidence-based personalized medicine.International review of psychiatry (Abingdon, England) · 2021Review
- A review of sleep disturbance in adults prescribed medications for opioid use disorder: potential treatment targets for a highly prevalent, chronic problem.Sleep medicine · 2021Review
- Challenges for Women Entering Treatment for Opioid Use Disorder.Current psychiatry reports · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSleep disturbance is common in patients with opioid use disorder (OUD) receiving medication for addiction treatment. Differences between patients on the two primary agonist medications-methadone and buprenorphine-are not well understood.
methodsIn patients receiving either methadone or buprenorphine treatment for OUD, we examined sleep continuity and architecture using ambulatory monitoring to gather both an objective measure (daily sleep EEG; M = 5.76 days, SD = 1.46) and a subjective measure (daily sleep diary; M = 54.10 days, SD = 25.10) of sleep.
resultsPatients treated with buprenorphine versus methadone did not differ on any measure of sleep continuity or architecture. Women had longer EEG-derived total sleep time than men (d = -0.68, 95 % CI -1.32 to -0.09), along with lower %N2 (d = 0.94, 95 % CI 0.34-1.64) and greater %N3 (d = -0.94, 95 % CI -1.61 to -0.32). Self-reported sleep differed from EEG-derived estimates: wake after sleep onset was greater by EEG than by diary (d = 2.58, 95 % CI 1.74-3.63), and total sleep time and sleep efficiency were lower by EEG than by diary (d for sleep time = 2.93, 95 % CI 2.06-4.14; d for efficiency = 1.69, 95 % CI 0.98-2.49).
conclusionsPatients treated with buprenorphine or methadone did not substantively differ in ambulatory measures of sleep. With both medications, there was a discrepancy between objective and subjective sleep measures. Further confirmatory evidence would inform the development of sleep-related recommendations for OUD patients undergoing agonist treatment.
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