Evidence map›Paper›PMID 31816479›Full record

ArticleEpilepsy & behavior : E&B2020

Cortical thickness in childhood left focal epilepsy: Thinning beyond the seizure focus.

Emanuel M Boutzoukas, Jason Crutcher, Eduardo Somoza, Leigh N Sepeta, Xiaozhen You, William D Gaillard, Gregory L Wallace, Madison M Berl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Emanuel M BoutzoukasComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA.
Jason CrutcherLaboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA.
Eduardo SomozaComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA.
Leigh N SepetaComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA; Department of Psychiatry and Behavioral Sciences, The George Washington University, Washington, DC, USA.
Xiaozhen YouComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA; Department of Pediatrics and Neurology, The George Washington University, Washington, DC, USA.
William D GaillardComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA; Department of Pediatrics and Neurology, The George Washington University, Washington, DC, USA.
Gregory L WallaceLaboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA; Department of Speech, Language, and Hearing Sciences, The George Washington University, Washington, DC, USA.
Madison M BerlComprehensive Pediatric Epilepsy Program, Children's National Medical Center, Washington, DC, USA; Department of Psychiatry and Behavioral Sciences, The George Washington University, Washington, DC, USA. Electronic address: mberl@childrensnational.org.
Children's National · USGeorge Washington University · USNational Institute of Mental Health · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Plasticity of Language Networks in Childhood EpilepsyR01NS044280 · NINDS · CHILDREN'S NATIONAL MEDICAL CENTER · PI GAILLARD, WILLIAM DAVIS · 2002 to 2006
$1.9M
Imaging the Impact of Childhood Epilepsy on Memory Development - SupplementK23NS093152 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI SEPETA, LEIGH · 2018 to 2023
$912k
Cognitive Impairment Moderated by Working Memory in Pediatric Partial EpilepsyK23NS065121 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI BERL, MADISON MEHALANI · 2011 to 2015
$825k
NCATS NIH HHS UL1 TR001876NICHD NIH HHS U54 HD090257NINDS NIH HHS K23 NS065121NINDS NIH HHS K23 NS093152NINDS NIH HHS R01 NS044280
6 · The paper itself

Abstract

objectiveStructural brain differences are found in adults and children with epilepsy, yet pediatric samples have been heterogeneous regarding seizure type, magnetic resonance imaging (MRI) findings, and hemisphere of seizure focus. This study examines whether cortical thickness and surface area differ between children with left-hemisphere focal epilepsy (LHE) and age-matched typically developing (TD) peers. We examined whether age differentially moderated cortical thickness between groups and if cortical thickness was associated with duration of epilepsy, seizure frequency, or neuropsychological functioning.

methodsThirty-five children with LHE and 35 TD children completed neuropsychological testing and 3T MR imaging. Neuropsychological measures included general intelligence and executive functioning. All MRIs were normal. Surface-based morphometric processing and analyses were conducted using FreeSurfer 6.0. Regression analyses compared age by cortical thickness differences between groups. Correlational analyses examined associations between cortical thickness in these areas with neuropsychological functioning or epilepsy characteristics.

resultsLeft-hemisphere focal epilepsy displayed decreased cortical thickness bilaterally compared to TD controls across 6 brain regions but no differences in surface area. Moderation analyses revealed quadratic relationships between age and cortical thickness for left frontoparietal-cingulate and right superior frontal regions. Higher performance intelligence quotient (IQ) (PIQ) and verbal IQ (VIQ) and fewer parent reported executive function problems were associated with greater cortical thickness in TD children. SIGNIFICANCE: Children with LHE displayed thinner cortex extending beyond the hemisphere of seizure focus. The nonlinear pattern of cortical thickness across age occurring in TD children is not evident in the same manner in children with LHE. These differences in cortical thickness patterns were greatest in children 8-12 years old. Greater cortical thickness was associated with higher IQ and fewer executive control problems in daily activities in TD children. Thus, differences in cortical thickness in the absence of differences in surface area, suggest cortical thickness may be a sensitive proxy of subtle neuroanatomical changes that are related to neuropsychological functioning.

Indexed as

AdolescentAdultCerebral CortexChildCognitive DysfunctionEpilepsies, PartialExecutive FunctionFemaleHumansIntelligenceMagnetic Resonance ImagingMaleNeuropsychological TestsBrain developmentExecutive functioningFreeSurferNeuropsychologyPediatric

Identifiers

PMID31816479
PMCPMC6962541
OpenAlexW2991904271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.