ArticleJournal of applied clinical medical physics2020
Evaluation of complexity and deliverability of prostate cancer treatment plans designed with a knowledge-based VMAT planning technique.
Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Systematic implementation of rapidplan for prostate cancer: toward a unified knowledge-based planning model.Scientific reports · 2025Article
- Comparative evaluation of two dose-volume histogram prediction tools for treatment planning: Treatment planning quality and dose verification accuracy.Technical innovations & patient support in radiation oncology · 2025Article
- Quality and mechanical efficiency of automated knowledge-based planning for volumetric-modulated arc therapy in head and neck cancer.Journal of applied clinical medical physics · 2025Article
- Enhancing dosimetric practices through knowledge-based predictive models: a case study on VMAT prostate irradiation.Frontiers in oncology · 2024Article
- Evaluation of complexity and deliverability of IMRT treatment plans for breast cancer.Scientific reports · 2023Article
- Implementation, Dosimetric Assessment, and Treatment Validation of Knowledge-Based Planning (KBP) Models in VMAT Head and Neck Radiation Oncology.Biomedicines · 2023Article
- Dose Prediction Models Based on Geometric and Plan Optimization Parameter for Adjuvant Radiotherapy Planning Design in Cervical Cancer Radiotherapy.Journal of healthcare engineering · 2021Article
- Personalized Treatment Planning Automation in Prostate Cancer Radiation Oncology: A Comprehensive Dosimetric Study.Frontiers in oncology · 2021Article
- Quantitative Comparison of Knowledge-Based and Manual Intensity Modulated Radiation Therapy Planning for Nasopharyngeal Carcinoma.Frontiers in oncology · 2020Article
- Dosimetric Evaluation of Simplified Knowledge-Based Plan with an Extensive Stepping Validation Approach in Volumetric-Modulated Arc Therapy-Stereotactic Body Radiotherapy for Lung Cancer.Journal of medical physicsArticle
- A Study on Synchronous Bilateral Breast Cancer Radiotherapy Based on an Accelerator Integrated with Optical Surface Monitoring System.Technology in cancer research & treatmentArticle
- Error Detectability of Isodose Volumes as ROIs in Prostate Intensity-modulated RT QA.In vivo (Athens, Greece)Article
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Authors and funding
2 authors.
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Abstract
purposeKnowledge-based planning (KBP) techniques have been reported to improve plan quality, efficiency, and consistency in radiation therapy. However, plan complexity and deliverability have not been addressed previously for treatment plans guided by an established in-house KBP system. The purpose of this work was to assess dosimetric, mechanical, and delivery properties of plans designed with a common KBP method for prostate cases treated via volumetric modulated arc therapy (VMAT).
methodsThirty-one prostate patients previously treated with VMAT were replanned with an in-house KBP method based on the overlap volume histogram. VMAT plan complexities of the KBP plans and the reference clinical plans were quantified via monitor units, modulation complexity scores, the edge metric, and average leaf motion per degree of gantry rotation. Each set of plans was delivered to the same diode array and agreement between computed and measured dose distributions was evaluated using the gamma index. Varying percent dose-difference (1-3%) and distance-to-agreement (1 mm to 3 mm) thresholds were assessed for gamma analyses.
resultsKnowledge-based planning (KBP) plans achieved average reductions of 6.4 Gy (P < 0.001) and 8.2 Gy (P < 0.001) in mean bladder and rectum dose compared to reference plans, while maintaining clinically acceptable target dose. However, KBP plans were significantly more complex than reference plans in each evaluated metric (P < 0.001). KBP plans also showed significant reductions (P < 0.05) in gamma passing rates at each evaluated criterion compared to reference plans.
conclusionsWhile KBP plans had significantly reduced bladder and rectum dose, they were significantly more complex and had significantly worse quality assurance outcomes than reference plans. These results suggest caution should be taken when implementing an in-house KBP technique.
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