ArticleJournal of applied clinical medical physics2020
"Dose of the day" based on cone beam computed tomography and deformable image registration for lung cancer radiotherapy.
Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of online dose-guided adaptive fractionation for intact prostate radiotherapy.Journal of applied clinical medical physics · 2026Article
- Optimization of CBCT-guided imaging schedules for left-sided postmastectomy radiotherapy using VMAT: A dosimetric, radiobiological, and cost analysis.Journal of applied clinical medical physics · 2026Article
- Time series analysis of dosimetric changes in target volumes and organs at risk monitored by cone beam computed tomography during radiotherapy for non-small-cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- Adaptive treatment margins to reduce organs at risk dose in patients with no or minimal anatomical changes in radiotherapy of non-small cell lung cancer.Physics and imaging in radiation oncology · 2025Article
- Evaluation of cumulative dose distributions from external beam radiation therapy using CT-to-CBCT deformable image registration (DIR) for cervical cancer patients.Journal of applied clinical medical physics · 2025Article
- Evaluating synthetic computed tomography images for adaptive radiotherapy decision making in head and neck cancer.Physics and imaging in radiation oncology · 2023Article
- The geometric and dosimetric accuracy of kilovoltage cone beam computed tomography images for adaptive treatment: a systematic review.BJR open · 2023Article
- Onboard cone-beam CT-based replan evaluation for head and neck proton therapy.Journal of applied clinical medical physics · 2022Article
- Clinical suitability of deep learning based synthetic CTs for adaptive proton therapy of lung cancer.Medical physics · 2021Article
- Concurrent chemoradiotherapy for stage III non-small-cell lung cancer: recent progress and future perspectives (a narrative review).Translational lung cancer research · 2021Review
- Adaptive Radiation Therapy in the Treatment of Lung Cancer: An Overview of the Current State of the Field.Frontiers in oncology · 2021Review
- Cone-Beam-CT Guided Adaptive Radiotherapy for Locally Advanced Non-small Cell Lung Cancer Enables Quality Assurance and Superior Sparing of Healthy Lung.Frontiers in oncology · 2020Article
- Unanticipated Radiation Replanning for Stage III Non-small Cell Lung Cancer.Advances in radiation oncologyArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeAdaptive radiotherapy (ART) has potential to reduce toxicity and facilitate safe dose escalation. Dose calculations with the planning CT deformed to cone beam CT (CBCT) have shown promise for estimating the "dose of the day". The purpose of this study is to investigate the "dose of the day" calculation accuracy based on CBCT and deformable image registration (DIR) for lung cancer radiotherapy.
methodsA total of 12 lung cancer patients were identified, for which daily CBCT imaging was performed for treatment positioning. A re-planning CT (rCT) was acquired after 20 Gy for all patients. A virtual CT (vCT) was created by deforming initial planning CT (pCT) to the simulated CBCT that was generated from deforming CBCT to rCT acquired on the same day. Treatment beams from the initial plan were copied to the vCT and rCT for dose calculation. Dosimetric agreement between vCT-based and rCT-based accumulated doses was evaluated using the Bland-Altman analysis.
resultsMean differences in dose-volume metrics between vCT and rCT were smaller than 1.5%, and most discrepancies fell within the range of ± 5% for the target volume, lung, esophagus, and heart. For spinal cord D
conclusionThis study demonstrated a reasonable agreement in dose-volume metrics between dose accumulation based on vCT and rCT, with the exception for cases with poor CBCT image quality. These findings suggest potential utility of vCT for providing a reasonable estimate of the "dose of the day", and thus facilitating the process of ART for lung cancer.
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