ArticleJournal of veterinary internal medicine2020
Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- One Health Insights into Pulmonary Hypertension: Bridging Human and Canine Medicine.Veterinary sciences · 2026Review
- Development and evaluation of a composite echocardiographic score for predicting pulmonary hypertension severity in dogs.Journal of veterinary internal medicine · 2026Article
- Ante-mortem diagnosis of unilateral pulmonary vein stenosis in a cat: a case report.Acta veterinaria Scandinavica · 2025Article
- A Retrospective Study of Sildenafil Administration in 55 Cats with Cardiopulmonary Disease (2009-2021).Animals : an open access journal from MDPI · 2024Article
- The Role of Personalized Medicine in Companion Animal Cardiology.The Veterinary clinics of North America. Small animal practice · 2023Review
- Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough.Journal of veterinary internal medicine · 2023Article
- Effects of a Soluble Guanylate Cyclase Stimulator Riociguat on Contractility of Isolated Pulmonary Artery and Hemodynamics of U46619-Induced Pulmonary Hypertension in Dogs.Veterinary sciences · 2023Article
- A dog presenting with syncope due to two different etiologies.Journal of advanced veterinary and animal research · 2022Article
- Investigation of Beraprost Sodium on Cardiac Function and Hemodynamics in Canine Models of Chronic Pulmonary Hypertension.Frontiers in veterinary science · 2022Article
- The prevalence of pulmonary hypertension assessed using the pulmonary vein-to-right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis.BMC veterinary research · 2021Article
- Efficacy of Beraprost Sodium Combined with Sildenafil and Its Effects on Vascular Endothelial Function and Inflammation in Patients Experiencing Left Heart Failure Complicated with Pulmonary Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension.Journal of veterinary internal medicine · 2020Article
- Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil.Journal of veterinary internal medicine · 2020Article
- Echocardiographic Changes Related to Pulmonary Hypertension in Preweaned Dairy Calves With Bronchopneumonia: A Case-Control Study in Commercial Dairy Farms.Journal of veterinary internal medicineArticle
- Platelet hyperresponsiveness and increased platelet-neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension.Journal of veterinary internal medicineArticle
- The echocardiographic pulmonary to left atrial ratio: A noninvasive variable for the hemodynamic classification of pulmonary hypertension in dogs.Journal of veterinary internal medicineArticle
- Echocardiographic characteristics of dogs with pulmonary hypertension secondary to respiratory diseases.Journal of veterinary internal medicineArticle
- Tricuspid valve chordal rupture in a dog with pulmonary hypertension.Open veterinary journalArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPulmonary hypertension (PH) can develop secondary to many common cardiopulmonary diseases, and the use of sildenafil has improved care of affected dogs.
objectiveTo evaluate response to sildenafil in dogs with respiratory-associated PH. ANIMALS: Twenty-five dogs with PH.
methodsProspective clinical trial. Doppler echocardiography identified dogs with moderate to severe PH, and additional tests were performed to detect underlying diseases. A 17-point quality of life (QOL) questionnaire was completed, and sildenafil was prescribed, along with other medications deemed necessary for the management of clinically diagnosed respiratory diseases. After 30 days, dogs returned to the hospital for repeat echocardiogram and QOL survey.
resultsThe median age was 12.4 years, and most dogs were small breed dogs (median weight, 6.5 kg). Syncope (64%), cough (56%), and respiratory difficulty (32%) were the most common presenting complaints. Respiratory diseases associated with PH included tracheobronchomalacia, pulmonary fibrosis, inflammatory airway disease, and brachycephalic syndrome, with multiple diseases in some dogs. Eight of 25 dogs (32%) died or were euthanized within 1 month. In the remaining dogs, tricuspid regurgitation pressure gradient (83.0 ± 17.4 mm Hg before, 55.4 ± 17.4 mm Hg after) and QOL scores were significantly improved after 1 month of sildenafil. Fifty percent mortality was reached 6 months after study entry, with 4 dogs alive 5 years after diagnosis. CONCLUSIONS AND CLINICAL IMPORTANCE: Sildenafil responsiveness is variable in dogs with respiratory-associated PH, but improved QOL was demonstrated in dogs surviving >1 month, and long-term survival was noted in some cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.