Evidence map›Paper›PMID 31816081›Full record

ReviewRheumatology (Oxford, England)2019

Pathology of immune-mediated tissue lesions following treatment with immune checkpoint inhibitors.

Hajir Ibraheim, Esperanza Perucha, Nick Powell

Abstract readReview
In one paragraph

Review in Rheumatology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Utilizing Biologics in Drug Desensitization.Current allergy and asthma reports · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. A Review of Cancer Immunotherapy Toxicity: Immune Checkpoint Inhibitors.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021
    Review
  17. [Research Progress of Immune Checkpoint Inhibitor-associated Myocarditis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
    Article
  18. Adverse events induced by immune checkpoint inhibitors.Current opinion in immunology · 2021
    Review
  19. Anti-PD-1-Induced Hidradenitis Suppurativa.Dermatopathology (Basel, Switzerland) · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hajir IbraheimDivision of Digestive Diseases, Faculty of Medicine, Imperial College London, UK.
Esperanza PeruchaCentre for Inflammation Biology and Cancer Immunology, Centre for Rheumatic Diseases, King's College London.
Nick PowellDivision of Digestive Diseases, Faculty of Medicine, Imperial College London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune check point inhibitor (CPI) therapy has revolutionized treatment paradigms for several cancers, but at the cost of triggering a diverse spectrum of immune-mediated injury to non-cancer tissues. The complex biology of these toxicities remains incompletely understood, partly because tissue acquisition from affected areas can be challenging to retrieve, thus hindering development of targeted therapy. Here, we review the literature describing pathology of immune-mediated tissue lesions including gastrointestinal, skin, rheumatic, pulmonary, cardiac, renal and hepatic lesions and highlight key immunological insights.

Indexed as

Antineoplastic Agents, ImmunologicalChemical and Drug Induced Liver InjuryDrug EruptionsGastrointestinal DiseasesHumansImmunologic FactorsImmunotherapyKidney DiseasesLung DiseasesMyocarditisNeoplasmsRheumatic DiseasesAntineoplastic Agents, ImmunologicalImmunologic FactorsCPI cardiac toxicityCPI enterocolitisCPI hepatitisCPI pulmonary toxicityCPI renal injuryCPI rheumatic toxicityCPI skin toxicityirAE pathology

Identifiers

PMID31816081
PMCPMC6900915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.