Evidence map›Paper›PMID 31816060›Full record

ArticleBlood advances2019

Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor.

Margaret Nieborowska-Skorska, Elisabeth M Paietta, Ross L Levine, Hugo F Fernandez, Martin S Tallman, Mark R Litzow, Tomasz Skorski

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Margaret Nieborowska-SkorskaSol Sherry Thrombosis Research Center and Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Elisabeth M PaiettaAlbert Einstein College of Medicine-Montefiore Medical Center, Bronx, NY.
Ross L LevineCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY.
Hugo F FernandezMoffitt Malignant Hematology and Cellular Therapy at Memorial Healthcare System, Pembroke Pines, FL; and.
Martin S TallmanCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY.
Mark R LitzowDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Tomasz SkorskiSol Sherry Thrombosis Research Center and Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Memorial Sloan Kettering Cancer Center · USTemple University · USAlbert Einstein College of Medicine · USMayo Clinic in Arizona · USMemorial Healthcare System · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6M
ECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1M
Network Lead Academic Participating Site: Memorial Sloan Kettering Cancer CenterUG1CA233290 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAROL AGHAJANIAN, Darren Feldman · 2019 to 2026
$10.2M
Targeting DNA repair to eradicate TKi-refractory/resistant CML and Ph+ALLR01CA186238 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI SKORSKI, TOMASZ · 2014 to 2024
$4.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA186238NCI NIH HHS U10 CA180820NCI NIH HHS U24 CA196172NCI NIH HHS UG1 CA233290
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Line, TumorCore Binding Factor Alpha 2 SubunitHumansLeukemiaOncogene Proteins, FusionPoly(ADP-ribose) Polymerase InhibitorsRUNX1 Translocation Partner 1 ProteinAML1-ETO fusion protein, humanCore Binding Factor Alpha 2 SubunitOncogene Proteins, FusionPoly(ADP-ribose) Polymerase InhibitorsRUNX1 Translocation Partner 1 Protein

Identifiers

PMID31816060
PMCPMC6963253
OpenAlexW2993091173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.