ArticlePloS one2019
The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus).
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 88 citations in OpenAlex.
- Comprehensive Proteomics Reveals Acute Osmoregulatory Responses in the Intestine ofAnimals : an open access journal from MDPI · 2026Article
- A Butyrate-Producing Probiotic,Microorganisms · 2026Article
- Sodium butyrate improved intestinal function in normal and glyphosate-challenged Nile tilapia (Oreochromis niloticus L.).Fish physiology and biochemistry · 2026Article
- A Novel Indigenous Probiotic, Clostridium moniliforme G18, Confers Health Benefits to Mud Crabs (Scylla paramamosain).Probiotics and antimicrobial proteins · 2026Article
- Multi-Omics Analysis Uncovers Acute Hypoxia-Induced Gut Damage and the Underlying Protective Mechanisms of Probiotic Clostridium butyricum B3 in Yellow Catfish (Pelteobagrus fulvidraco).Probiotics and antimicrobial proteins · 2026Article
- Valorization of Fruit and Vegetable Peels Waste as Probiotic Consortium for Sustainable Aquaculture of Cyprinus Carpio.Probiotics and antimicrobial proteins · 2026Article
- Fish-Derived Clostridium butyricum LZK-08: Genomic Insights and Probiotic Evaluation in Largemouth Bass.Probiotics and antimicrobial proteins · 2026Article
- Effects of dietary antimicrobial peptides on growth performance, antioxidant capacity, immune response and disease resistance of juvenile Nile tilapia (Frontiers in physiology · 2026Article
- Dietary Green Tea Enhances the Growth, Antioxidant Capacity, and Abundance of Beneficial Intestinal Flora of Grass Carp (Animals : an open access journal from MDPI · 2025Article
- Article
- Effects of Dietary Supplementation with Three Different Probiotics on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota in Grass Carp (Microorganisms · 2025Article
- Effects of DietaryMicroorganisms · 2025Article
- Effect of dietaryFrontiers in immunology · 2025Article
- Isolation and Evaluation of Potential Use of Prebiotics-Utilizing Butyrate-Producing Bacteria inAquaculture nutrition · 2025Article
- Effects of supplementation with freeze-dried Clostridium butyricum powder after replacement of fishmeal with cottonseed protein concentrate on growth performance, immune response, and intestinal microbiota of Litopenaeus vannamei.BMC veterinary research · 2024Article
- Comparative analysis of gut microbiome in Pangasionodon hypopthalmus and Labeo catla during health and disease.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Polyphenol-rich extracts enhance growth, immune function, and antioxidant defense in juvenile rainbow trout (Frontiers in nutrition · 2024Article
- Effects of Fishmeal Substitution with Mealworm Meals (Aquaculture nutrition · 2024Article
- Long-Term Phellodendri Cortex Supplementation in the Tiger Grouper (Life (Basel, Switzerland) · 2023Article
- Bacterial diseases in marine fish species: current trends and future prospects in disease management.World journal of microbiology & biotechnology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was conducted to assess the effects of dietary Clostridium butyricum on the growth, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus). Three hundreds of tilapia (56.21 ± 0.81 g) were divided into 5 groups and fed a diet supplemented with C. butyricum at 0, 1 x 104, 1 x 105, 1 x 106 or 1 x 107 CFU g-1 diet (denoted as CG, CB1, CB2, CB3 and CB4, respectively) for 56 days. Then 45 fish from each group were intraperitoneally injected with Streptococcus agalactiae, and the mortality was recorded for 14 days. The results showed that dietary C. butyricum significantly improved the specific growth rate (SGR) and feed intake in the CB2 group and decreased the cumulative mortality post-challenge with S. agalactiae in the CB2, CB3 and CB4 groups. The serum total antioxidant capacity and intestinal interleukin receptor-associated kinase-4 gene expression were significantly increased, and serum malondialdehyde content and diamine oxidase activity were significantly decreased in the CB1, CB2, CB3 and CB4 groups. Serum complement 3 and complement 4 concentrations and intestinal gene expression of tumour necrosis factor α, interleukin 8, and myeloid differentiation factor 88 were significantly higher in the CB2, CB3 and CB4 groups. Intestinal toll-like receptor 2 gene expression was significantly upregulated in the CB3 and CB4 groups. Dietary C. butyricum increased the diversity of the intestinal microbiota and the relative abundance of beneficial bacteria (such as Bacillus), and decreased the relative abundance of opportunistic pathogenic bacteria (such as Aeromonas) in the CB2 group. These results revealed that dietary C. butyricum at a suitable dose enhanced growth performance, elevated humoral and intestinal immunity, regulated the intestinal microbial components, and improved disease resistance in tilapia. The optimal dose was 1 x 105 CFU g-1 diet.
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