ArticlePLoS computational biology2019
Stability of spontaneous, correlated activity in mouse auditory cortex.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
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- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.The European journal of neuroscience · 2025Article
- Hierarchical communities in the larvalProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Network state changes in sensory thalamus represent learned outcomes.Nature communications · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales.Nature communications · 2024Article
- Identifying properties of pattern completion neurons in a computational model of the visual cortex.PLoS computational biology · 2023Article
- The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex.Nature neuroscience · 2023Article
- Dynamic structure of motor cortical neuron coactivity carries behaviorally relevant information.Network neuroscience (Cambridge, Mass.) · 2023Article
- Correction: Stability of spontaneous, correlated activity in mouse auditory cortex.PLoS computational biology · 2022Article
- Neuronal activity in sensory cortex predicts the specificity of learning in mice.Nature communications · 2022Article
- Stable representation of a naturalistic movie emerges from episodic activity with gain variability.Nature communications · 2021Article
- Identification and quantification of neuronal ensembles in optical imaging experiments.Journal of neuroscience methods · 2021Article
- Neuronal Graphs: A Graph Theory Primer for Microscopic, Functional Networks of Neurons Recorded by Calcium Imaging.Frontiers in neural circuits · 2021Review
- Autonomous emergence of connectivity assemblies via spike triplet interactions.PLoS computational biology · 2020Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Neural systems can be modeled as complex networks in which neural elements are represented as nodes linked to one another through structural or functional connections. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system's topological organization and to better understand its function. Here, we used two-photon calcium imaging to record spontaneous activity from the same set of cells in mouse auditory cortex over the course of several weeks. We reconstruct functional networks in which cells are linked to one another by edges weighted according to the correlation of their fluorescence traces. We show that the networks exhibit modular structure across multiple topological scales and that these multi-scale modules unfold as part of a hierarchy. We also show that, on average, network architecture becomes increasingly dissimilar over time, with similarity decaying monotonically with the distance (in time) between sessions. Finally, we show that a small fraction of cells maintain strongly-correlated activity over multiple days, forming a stable temporal core surrounded by a fluctuating and variable periphery. Our work indicates a framework for studying spontaneous activity measured by two-photon calcium imaging using computational methods and graphical models from network science. The methods are flexible and easily extended to additional datasets, opening the possibility of studying cellular level network organization of neural systems and how that organization is modulated by stimuli or altered in models of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.