ReviewCurrent opinion in psychiatry2020
The development of the social brain in baby siblings of children with autism.
Review in Current opinion in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Cerebellar Contributions to Cerebral Connectivity in Severe Mental Illness: A Developmental Cascade and Predictive-Modeling Framework with Autistic Disorder as the Focal Case.Brain sciences · 2026Review
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- Investigating cerebral blood flow dysregulation and serum zinc correlation in 2-4 year-old children with autism spectrum disorder.European journal of medical research · 2025Article
- Structural and functional whole brain changes in autism spectrum disorder at different age stages.European child & adolescent psychiatry · 2025Article
- Correlation between autistic traits and brain functional connectivity in preschoolers with autism spectrum disorder: a resting state MEG study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Effects of transcranial direct current stimulation on brain activity and cortical functional connectivity in children with autism spectrum disorders.Frontiers in psychiatry · 2024Article
- The clinical effects of Orff music therapy on children with autism spectrum disorder: a comprehensive evaluation.Frontiers in neurology · 2024Article
- Inter-brain synchrony during mother-infant interactive parenting in 3-4-month-old infants with and without an elevated likelihood of autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Application of Three-Dimensional Pseudocontinuous Arterial Spin Labeling Perfusion Imaging in the Brains of Children With Autism.Frontiers in neurology · 2022Article
- Application of TBSS-based machine learning models in the diagnosis of pediatric autism.Frontiers in neurology · 2022Article
- Application of Quantitative Magnetic Resonance Imaging in the Diagnosis of Autism in Children.Frontiers in medicine · 2022Article
- Quantitative susceptibility mapping shows lower brain iron content in children with autism.European radiology · 2021Article
- Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purpose of reviewImpairments in social interaction/communication become apparent after 12 months of age in children who develop Autism spectrum disorder (ASD). Studies of baby siblings of children with ASD provide the means to detect changes in the brain that are present before behavioral symptoms appear. In this review, advances from brain imaging studies of infant siblings over the past 18 months are highlighted. RECENT
findingsDuring the first 2 months of life, functional differences in social brain regions and microstructural differences in dorsal language tracks are found in some high-risk baby siblings. At 4-6 months of age, differences in subcortical and cerebellum volumes and atypical cortical responses to social stimuli are evident. At 6 months, extra-axial cerebrospinal fluid is increased, and at 8 months there is evidence of cortical hyper-reactivity. Patterns of functional connectivity are distinct in infant siblings and suggest dysfunctional activation and integration of information across the cortex and neural networks underlying social behaviors. SUMMARY: Further replication in very large independent samples is needed to verify the majority of the findings discussed and understand how they are related within individual infants. Much more research is needed before translation to clinical practice.
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Registered trials
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