ArticleeLife2019
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans.The EMBO journal · 2026Article
- Proximity labeling at H3K9me3 reveals VRK-1 regulate global chromatin distribution inbioRxiv : the preprint server for biology · 2026Article
- Proteostasis Rebalancing by LET-607 Deficiency Promotes Longevity.Aging cell · 2026Article
- The transcription factor LSL-1 interacts with the chromatin factors HIM-17, XND-1 and BRA-2 to promote the germline-specific transcriptional repertoire and to safeguard germ cell fate inbioRxiv : the preprint server for biology · 2026Article
- WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans.Epigenetics & chromatin · 2026Article
- Chromatin remodeling by HIRA and FAS2 restricts geminivirus pathogenesis in plants.Virology journal · 2026Article
- Functional dissection of H3K4 methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development.Development (Cambridge, England) · 2025Article
- Lysosomes signal through the epigenome to regulate longevity across generations.Science (New York, N.Y.) · 2025Article
- A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance.Genetics · 2025Article
- Nuclear deformability depends on H3K9-methylated heterochromatin anchorage to the nuclear periphery in Caenorhabditis elegans.Genetics · 2025Article
- Epigenetics and individuality: from concepts to causality across timescales.Nature reviews. Genetics · 2025Review
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials.Medicinal research reviews · 2025Review
- Argonaute CSR-1A promotes H3K9me3 maintenance to protect somatic development in offspring.Nucleic acids research · 2025Article
- Caenorhabditis Elegans as a Model for Environmental Epigenetics.Current environmental health reports · 2025Review
- The evolutionary consequences of interactions between the epigenome, the genome and the environment.Evolutionary applications · 2024Review
- Anchorage of H3K9-methylated heterochromatin to the nuclear periphery helps mediate P-cell nuclear migration though constricted spaces inbioRxiv : the preprint server for biology · 2024Article
- The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.GeroScience · 2023Article
- The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.Nature aging · 2023Article
- Methylation across the central dogma in health and diseases: new therapeutic strategies.Signal transduction and targeted therapy · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Teresa Wei-Sy LeeDepartment of Cell Biology, Emory University School of Medicine, Atlanta, United States.ORCID 0000-0002-0149-5389
Heidi Shira DavidDepartment of Cell Biology, Emory University School of Medicine, Atlanta, United States.
Amanda Kathryn EngstromDepartment of Cell Biology, Emory University School of Medicine, Atlanta, United States.ORCID 0000-0002-6796-2752
Brandon Scott CarpenterDepartment of Cell Biology, Emory University School of Medicine, Atlanta, United States.ORCID 0000-0001-9939-1926
David John KatzDepartment of Cell Biology, Emory University School of Medicine, Atlanta, United States.ORCID 0000-0002-3040-1142
Emory University · US
Funding
IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MThe Function of LSD1 in Tau Mediated NeurodegenerationF31NS098663 · NINDS · EMORY UNIVERSITY · PI ENGSTROM, AMANDA KATHRYN · 2017 to 2019
$134kNIGMS NIH HHS K12 GM000680NIH HHS F31 NS098663-01A1NIH HHS F31 NS098663-02NIH HHS K12GM00680-15NIH HHS P40 OD010440NINDS NIH HHS F31 NS098663
Abstract
In
Indexed as
MutationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsHeterochromatinHistone-Lysine N-MethyltransferaseHistonesInheritance PatternsJumonji Domain-Containing Histone DemethylasesLongevityLysineMethylationCaenorhabditis elegans ProteinsHeterochromatinHistone-Lysine N-MethyltransferaseHistonesJumonji Domain-Containing Histone DemethylasesLysineMet-2 protein, C eleganswdr-5.1 protein, C elegansagingC. eleganschromatinchromosomesCOMPASSepigeneticsgene expressiongeneticsgenomicsheterochromatintransgenerational inheritance
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.