ArticleJournal of orthopaedic surgery and research2019
LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Exosome-derived LncRNAs in bone remodeling: recent advances and future directions for bone disease therapy.Stem cell research & therapy · 2026Review
- Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2.Journal of orthopaedic surgery and research · 2024Article
- Comprehensive analysis of epigenetics mechanisms in osteoporosis.Frontiers in genetics · 2023Review
- Osteoporosis pathogenesis and treatment: existing and emerging avenues.Cellular & molecular biology letters · 2022Review
- LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment.Scientific reports · 2022Article
- Silencing of LncRNA KCNQ1OT1 confers an inhibitory effect on renal fibrosis through repressing miR-124-3p activity.Bioengineered · 2022Article
- Long noncoding RNA profiling reveals that LncRNA BTN3A2 inhibits the host inflammatory response toFrontiers in immunology · 2022Article
- Recent advances in the epigenetics of bone metabolism.Journal of bone and mineral metabolism · 2021Review
- LINC00899 promotes osteogenic differentiation by targeting miR-374a and RUNX2 expression.Experimental and therapeutic medicine · 2021Article
- Correlation analysis of long non-coding RNA TUG1 with disease risk, clinical characteristics, treatment response, and survival profiles of adult PhJournal of clinical laboratory analysis · 2021Article
- The Role of Epigenomics in Osteoporosis and Osteoporotic Vertebral Fracture.International journal of molecular sciences · 2020Review
- Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis.Arthritis research & therapy · 2020Review
- An emerging potential therapeutic target for osteoporosis: LncRNA H19/miR-29a-3p axis.European journal of histochemistry : EJH · 2020Article
- Retraction Note: LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts.Journal of orthopaedic surgery and research · 2020Article
- The roles of miRNA, lncRNA and circRNA in the development of osteoporosis.Biological research · 2020Review
- The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis.International journal of molecular sciences · 2020Review
- The regulatory roles of long noncoding RNAs in osteoporosis.American journal of translational research · 2020Review
- Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis.Frontiers in genetics · 2020Review
- Involvement of Noncoding RNAs in the Differentiation of Osteoclasts.Stem cells international · 2020Review
Corrections and comments
- Retraction · 2020-10-12Author Unresponsive · Lack of IRB/IACUC Approval and/or Compliance ·
- Retracted
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong non-coding RNA (LncRNA) TUG1 plays critical roles in the development of human cancers. Its inhibition has been proved to participate in ankylosing spondylitis, which is an inverse pathological procedure of osteoporosis. In the present study, we aim to investigate the role of lncRNA TUG1 in ankylosing spondylitis. MATERIALS AND
methodsExpressions of lncRNA TUG1 in plasma of 98 patients with osteoporosis and 60 healthy participants were detected by real-time quantitative PCR (RT-qPCR). Diagnostic values of lncRNA CASC11 for osteoclasts were performed by the ROC curve with osteoporosis patients as positive and healthy participants as negative. All experiments were repeated 3 times. Mean ± standard deviation was calculated.
resultsWe found that plasma lncRNA TUG1 was upregulated in osteoporosis patients than in healthy participants. Upregulation of plasma lncRNA TUG1 distinguished osteoporosis patients from healthy participants. LncRNA TUG1 level increased with the advances of clinical stages. Over-expression of lncRNA TUG1 promoted the proliferation and inhibited the apoptosis of mice osteoclasts, while lncRNA TUG1 siRNA silencing played an opposite role. In addition, lncRNA TUG1 over-expression led to downregulated PTEN, while lncRNA TUG1 siRNA silencing played an opposite role.
conclusionTherefore, lncRNA TUG1 is upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts. lncRNA TUG1 knockdown may serve as a promising therapeutic target for osteoporosis by inhibiting the proliferation and promoting the apoptosis of osteoclasts through PTEN.
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