Evidence map›Paper›PMID 31815449›Full record

ArticleAnalytical chemistry2020

Facile Discovery and Quantification of Isonitrile Natural Products via Tetrazine-Based Click Reactions.

Yao-Bing Huang, Wenlong Cai, Antonio Del Rio Flores, Frederick F Twigg, Wenjun Zhang

Abstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.Annual review of chemical and biomolecular engineering · 2022
    Review
  13. Kupyaphores are zinc homeostatic metallophores required for colonization ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yao-Bing HuangJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources , Nanjing Forestry University , Nanjing 210037 , China.ORCID 0000-0002-3783-862X
Wenlong CaiDepartment of Chemical and Biomolecular Engineering , University of California , Berkeley , California 94720 , United States.
Antonio Del Rio FloresDepartment of Chemical and Biomolecular Engineering , University of California , Berkeley , California 94720 , United States.ORCID 0000-0001-5893-3557
Frederick F TwiggDepartment of Chemical and Biomolecular Engineering , University of California , Berkeley , California 94720 , United States.
Wenjun ZhangDepartment of Chemical and Biomolecular Engineering , University of California , Berkeley , California 94720 , United States.ORCID 0000-0001-9348-972X

Funding

In Situ Natural Product Labeling and ApplicationsDP2AT009148 · NCCIH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, WENJUN · 2015 to 2020
$2.8M
NCCIH NIH HHS DP2 AT009148
6 · The paper itself

Abstract

A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. This method was successfully applied to the rediscovery of diisonitrile antibotic SF2768 from an unknown strain

Indexed as

Biological ProductsClick ChemistryMolecular StructureNitrilesStreptomycesTetrazolesBiological ProductsNitrilesTetrazoles

Identifiers

PMID31815449
PMCPMC7718942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.