Evidence map›Paper›PMID 31815423›Full record

ArticleACS nano2019

Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant

Thushara Galbadage, Dongdong Liu, Lawrence B Alemany, Robert Pal, James M Tour, Richard S Gunasekera, Jeffrey D Cirillo

Open access · bronzeAbstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Treatment of lung diseasesMaterials today. Bio · 2025
    Review
  8. Article
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  11. Article
  12. Article
  13. Review
  14. Polydopamine-Coated Copper-Doped CoMaterials (Basel, Switzerland) · 2024
    Article
  15. Artificial molecular motors in biological applications.Frontiers in molecular biosciences · 2024
    Review
  16. Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023
    Review
  17. Article
  18. Antibiotics and Bacterial Resistance-A Short Story of an Endless Arms Race.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Thushara GalbadageDepartment of Microbial Pathogenesis and Immunology , Texas A&M Health Science Center , Bryan , Texas 77807 , United States.
Lawrence B AlemanyORCID 0000-0001-7451-1020
Robert PalDepartment of Chemistry , Durham University , Durham DH1 3LE , United Kingdom.
Richard S GunasekeraDepartment Biological Science , Biola University , La Mirada , California 90639 , United States.
Jeffrey D CirilloDepartment of Microbial Pathogenesis and Immunology , Texas A&M Health Science Center , Bryan , Texas 77807 , United States.ORCID 0000-0003-3058-2702
Rice University · USTexas A&M Health Science Center · USBiola University · USDurham University · GB

Funding

Application of Imaging to Development of Tuberculosis InterventionsR01AI104960 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CIRILLO, JEFFREY D. · 2014 to 2018
$1.9M
Biotechnology and Biological Sciences Research CouncilNIAID NIH HHS R01 AI104960
6 · The paper itself

Abstract

Multidrug resistance in pathogenic bacteria is an increasing problem in patient care and public health. Molecular nanomachines (MNMs) have the ability to open cell membranes using nanomechanical action. We hypothesized that MNMs could be used as antibacterial agents by drilling into bacterial cell walls and increasing susceptibility of drug-resistant bacteria to recently ineffective antibiotics. We exposed extensively drug-resistant

Indexed as

AnimalsAnti-Bacterial AgentsCell DeathCell LineCell WallDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeLightMacrophagesMeropenemMiceMicrobial Sensitivity TestsMicrobial ViabilityMovementNanoparticlesAnti-Bacterial AgentsMeropenemantimicrobialantimicrobial resistanceextensive drug resistancelight activationmolecular nanomachinesmultidrug resistancenanomechanical action

Identifiers

PMID31815423
PMCPMC6933815
OpenAlexW2992153504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.