Evidence map›Paper›PMID 31815251›Full record

ArticleACS applied bio materials2018

Synthetic Polymer Nanoparticles Functionalized with Different Ligands for Receptor-mediated Transcytosis across Blood-Brain Barrier.

Qian Lu, Xiaoli Cai, Xian Zhang, Suiqiong Li, Yang Song, Dan Du, Prashanta Dutta, Yuehe Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  18. Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qian Lu *School of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Xiaoli Cai *School of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Xian ZhangSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Suiqiong LiSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Yang SongSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Dan DuSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Prashanta DuttaSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.
Yuehe LinSchool of Mechanical and Material Engineering, Washington State University, Pullman, Washington 99163, United States.

Funding

Multiscale Modeling of Transport though Blood Brain BarrierR01GM122081 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTA, PRASHANTA · 2016 to 2018
$763k
NIGMS NIH HHS R01 GM122081
6 · The paper itself

Abstract

Polymeric nanoparticles have been investigated as biocompatible and promising nano-carriers to deliver drugs across the blood-brain barrier (BBB). However, most of the polymeric nanoparticles cannot be observed without attaching them with fluorescent dyes. Generally complex synthesis process is required to attach fluorescent dye tracing molecules with drug carrier nanoparticles. In this paper, we synthesized a novel fluorescent polymer based on poly [Triphenylamine-4-vinyl-(P-methoxy-benzene)] (TEB). This polymer was prepared from TEB polymer through coprecipitation. Furthermore, three types of ligands, transferrin (TfR), lactoferrin (LfR) and lipoprotein (LRP), were covalently attached on the nanoparticle surface to improve the BBB transport efficiency. All of prepared TEB-based nanoparticles were biocompatible, exhibited excellent fluorescence properties and could be observed in vivo. The transcellular transportation of these TEB-based nanoparticles across the BBB was evaluated by observing the fluorescent intensity. The translocation study was performed in an

Indexed as

blood-brain barrier modelfluorescence polymer TEB nanoparticlesligandtransport efficiency

Identifiers

PMID31815251
PMCPMC6897387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.