Evidence map›Paper›PMID 31815195›Full record

ArticleCommunications biology2019

Structural basis for virulence regulation in

Justin T Cruite, Gabriela Kovacikova, Kenzie A Clark, Anne K Woodbrey, Karen Skorupski, F Jon Kull

Abstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXϕ.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Strain-dependentFrontiers in microbiology · 2026
    Article
  4. mBio · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Gut microbes · 2023
    Article
  9. Article
  10. Review
  11. Fatty Acids AbolishMicrobiology spectrum · 2023
    Article
  12. Article
  13. Article
  14. Structural Insights into Regulation of Vibrio Virulence Gene Networks.Advances in experimental medicine and biology · 2023
    Article
  15. Long Chain Fatty Acids and Virulence Repression in Intestinal Bacterial Pathogens.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Review
  17. Optimised Heterologous Expression and Functional Analysis of theInternational journal of molecular sciences · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Justin T Cruite1Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover, NH USA.
Gabriela Kovacikova3Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, NH USA.
Kenzie A Clark4Department of Chemistry, Dartmouth College, Hanover, NH USA.ORCID 0000-0003-0298-1124
Anne K Woodbrey2Guarini School of Graduate and Advanced Studies, Dartmouth College, Hanover, NH USA.
Karen Skorupski3Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, NH USA.
F Jon Kull1Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover, NH USA.

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Genetic Determinants of Virulence in Vibrio choleraeR37AI025096 · NIAID · DARTMOUTH COLLEGE · PI TAYLOR, RONALD K · 2007 to 2015
$4.3M
Structural Analysis of Vibrio cholerae Virulence Gene Regulatory ProteinsR01AI072661 · NIAID · DARTMOUTH COLLEGE · PI KULL, FREDRICK JON · 2007 to 2016
$4.3M
GENTICS DETERMINATION OF VIRULENCE OF VIBRIO CHOLERAER01AI025096 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SKORUPSKI, KAREN A · 1989 to 2016
$3.1M
Control of virulence in Vibrio cholerae by fatty acidsR01AI120068 · NIAID · DARTMOUTH COLLEGE · PI KULL, FREDRICK JON, SKORUPSKI, KAREN A · 2016 to 2020
$2.0M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Control of virulence in Vibrio cholerae by fatty acidsR56AI120068 · NIAID · DARTMOUTH COLLEGE · PI KULL, FREDRICK JON, SKORUPSKI, KAREN A · 2015 to 2015
$405k
NIAID NIH HHS R01 AI025096NIAID NIH HHS R01 AI072661NIAID NIH HHS R01 AI120068NIAID NIH HHS R37 AI025096NIAID NIH HHS R56 AI120068NIAID NIH HHS T32 AI007519NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P41 GM111244NIH HHS S10 OD018483
6 · The paper itself

Abstract

The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of

Indexed as

BileAllosteric RegulationBacterial ProteinsBinding SitesDNAFatty Acids, UnsaturatedModels, MolecularMolecular ConformationProtein BindingProtein Interaction Domains and MotifsProtein MultimerizationStructure-Activity RelationshipTranscription FactorsVibrio choleraeVirulenceBacterial ProteinsDNAFatty Acids, UnsaturatedtcpN protein, Vibrio choleraeTranscription FactorsPathogensX-ray crystallography

Identifiers

PMID31815195
PMCPMC6882843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.