Evidence map›Paper›PMID 31815176›Full record

ArticleNPJ Parkinson's disease2019

Acute levodopa dosing around-the-clock ameliorates REM sleep without atonia in hemiparkinsonian rats.

Vishakh Iyer, Quynh Vo, Anthony Mell, Siven Chinniah, Ashley Zenerovitz, Kala Venkiteswaran, Allen R Kunselman, Jidong Fang, Thyagarajan Subramanian

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. A novel rat model of body first subtype of Parkinson's disease.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Vishakh Iyer *1Program in Neuroscience, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN USA.ORCID 0000-0002-6827-3166
Quynh Vo *2Department of Neurology, West Virginia University School of Medicine, Morgantown, WV USA.
Anthony Mell *3Department of Neurology and Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Siven Chinniah3Department of Neurology and Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Ashley Zenerovitz3Department of Neurology and Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Kala Venkiteswaran3Department of Neurology and Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Allen R Kunselman4Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Jidong Fang5Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Thyagarajan Subramanian3Department of Neurology and Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA USA.
Pennsylvania State University · USIndiana University Bloomington · USWest Virginia University · US

Funding

Optogenetic and Chemogenetic Dissection of Cell TransplantsR01NS104565 · NINDS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SUBRAMANIAN, THYAGARAJAN · 2018 to 2022
$1.8M
NINDS NIH HHS R01 NS104565
6 · The paper itself

Abstract

Rapid-eye-movement (REM) sleep without atonia (RSWA), a marker of REM sleep behavior disorder (RBD), is frequently comorbid with Parkinson's disease (PD). Although rodent models are commonly used for studying PD, the neurobiological and behavioral correlates of RBD remain poorly understood. Therefore, we developed a behavior-based criteria to identify RSWA in the hemiparkinsonian rat model of PD. Video recordings of rats were analyzed, to develop a criteria consisting of behavioral signs that occurred during polysomnographically confirmed epochs of sleep-wake stages. The

Indexed as

Circadian rhythms and sleepParkinson's disease

Identifiers

PMID31815176
PMCPMC6884572
OpenAlexW2989679790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.