ArticleCurrent opinion in behavioral sciences2019
Early adversity and the regulation of gene expression: Implications for prenatal health.
Article in Current opinion in behavioral sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Probing the genomic landscape of human sexuality: a critical systematic review of the literature.Frontiers in genetics · 2023Pooled it
- Developmental origins of immune function: Maternal prenatal mood is associated with infant immune cell gene expression.Brain, behavior, and immunity · 2026Article
- Childhood adversity and autoimmune diseases: global research landscape, immune-related hotspots, and emerging trends from a bibliometric analysis of three databases.Frontiers in immunology · 2026Article
- Increased PLAGL1 Gene Methylation in Cord Blood is Positively Correlated with Brain Injury in Chorioamniotic Preterm Infants.Biochemical genetics · 2025Article
- Maternal adverse childhood experiences and perinatal outcomes: A retrospective inceptive cohort study.PloS one · 2025Article
- The role of the placenta-brain axis in psychoneuroimmune programming.Brain, behavior, & immunity - health · 2024Article
- Maternal early life stress is associated with pro-inflammatory processes during pregnancy.Brain, behavior, and immunity · 2023Article
- Microbiome and ileum transcriptome revealed the boosting effects of selenium yeast on egg production in aged laying hens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Which roads lead to depression in Latinas? A network analysis of prenatal depressive symptoms, discrimination, acculturative stress, and low birth weight.Research in nursing & health · 2022Article
- Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan.Frontiers in psychology · 2021Review
- Stress genomics revisited: gene co-expression analysis identifies molecular signatures associated with childhood adversity.Translational psychiatry · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Early life, including prenatal development and childhood, is a period of sensitivity, with potential for developmental programming under conditions of adversity. The intergenerational effects of early adversity have received attention, most often studied in relation to fetal development according to maternal exposures. Less often considered but critically important is the effect of early adversity on future prenatal risk (e.g., risk for preeclampsia, preterm birth), which threatens the health of mother and infant. The body's ability to turn collections of genes "on" or "off" across a range of tissues via receptor-driven transcription factors and epigenetic mechanisms (i.e., chemical modifications to the genome) in response to the perceived environment may help to explain such associations. This review aims to summarize discoveries surrounding the effects of early adversity on gene expression, emphasizing prenatal populations. First, we review findings from gene expression studies examining the effects of early adversity on various tissues known to contribute to prenatal health in adulthood. Next, we review several gene regulatory mechanisms thought to underlie differences in gene expression. Finally, we discuss potential implications for prenatal risk among early adversity-exposed mothers according to our current understanding of the biology that contributes to the development of prenatal syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.