Evidence map›Paper›PMID 31815152›Full record

ArticleJournal of immunology research2019

Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population.

Peng Wang, Lei Liu, Li-Fang Zhao, Chan-Na Zhao, Yan-Mei Mao, Yi-Lin Dan, Qian Wu, Xiao-Mei Li, De-Guang Wang, Hai-Feng Pan

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Association ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Peng WangCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, Jiangsu, China.
Lei LiuDepartment of Parasitology, Medical College of Soochow University, 199 Renai Road, Suzhou, Jiangsu, China.
Li-Fang ZhaoDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Chan-Na ZhaoDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Yan-Mei MaoDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Yi-Lin DanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Qian WuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Xiao-Mei LiDepartment of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, China.
De-Guang WangDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Hai-Feng PanDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.ORCID https://orcid.org/0000-0001-8218-5747
Anhui Medical University · CNAnhui Provincial Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study was to investigate the association of melatonin (MTN) pathway gene's single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE).

methodsWe recruited 495 SLE patients and 493 healthy controls, 11 tag SNPs in

resultsTwo SNPs of

conclusionsThe present study supported the genetic association of MTN pathway genes with SLE susceptibility and specific clinical manifestations, suggesting the potential role of MTN pathway genes in the pathogenesis and development of SLE.

Indexed as

Polymorphism, Single NucleotideAdultArylalkylamine N-AcetyltransferaseAsian PeopleCase-Control StudiesFemaleGene ExpressionGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansLupus Erythematosus, SystemicMaleMelatoninMiddle AgedAANAT protein, humanArylalkylamine N-AcetyltransferaseMelatoninMTNR1A protein, humanMTNR1B protein, humanReceptor, Melatonin, MT1Receptor, Melatonin, MT2

Identifiers

PMID31815152
PMCPMC6877953
OpenAlexW2988885653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.