ArticleJournal of diabetes research2019
Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass.
Article in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Combination of Calcitriol and Zoledronic Acid on PINP andDisease markers · 2022Trial
- Effects of GLP-1 Receptor Agonists on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus: A 52-Week Clinical Study.BioMed research international · 2021Trial
- Association between high-density bone composition and vertebral fracture risk in patients with type 2 diabetes: a longitudinal study.Internal and emergency medicine · 2026Article
- Utility of diffusion tensor imaging for assessing bone quality in type 2 diabetes: correlation with bone turnover biomarkers.Archives of osteoporosis · 2026Article
- Bone Microstructural Deterioration and miR-155/International journal of molecular sciences · 2025Article
- Age-related trends in trabecular bone scores and bone mineral density in Chinese men with type 2 diabetes mellitus: a cross-sectional study.Scientific reports · 2025Article
- Phytochemicals in Bone Therapy: Exploring Natural Alternatives for Bone Health.International journal of nanomedicine · 2025Review
- Trabecular Bone Score (TBS) in Individuals with Type 2 Diabetes Mellitus: An Updated Review.Journal of clinical medicine · 2023Review
- Article
- Early effects of ovariectomy on bone microstructure, bone turnover markers and mechanical properties in rats.BMC musculoskeletal disorders · 2022Article
- Article
- Micro-CT-Based Bone Microarchitecture Analysis of the Murine Skull.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Determination of risk factors of postoperative pneumonia in elderly patients with hip fracture: What can we do?PloS one · 2022Article
- Fracture risk assessment in diabetes mellitus.Frontiers in endocrinology · 2022Review
- The effects on type 2 diabetes mellitus mouse femoral bone achieved by anti-osteoporosis exercise interventions.Frontiers in endocrinology · 2022Article
- Association between Bone Mineral Density and Metabolic Syndrome among Reproductive, Menopausal Transition, and Postmenopausal Women.Journal of clinical medicine · 2021Article
- Sex-specific associations of serum insulin-like growth factor-1 with bone density and risk of fractures in Chinese patients with type 2 diabetes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The diabetes-fracture association in women with type 1 and type 2 diabetes is partially mediated by falls: a 15-year longitudinal study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Observational
- Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population.BMC musculoskeletal disorders · 2021Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T2DM is linked to an increase in the fracture rate as compared to the nondiabetic population even with normal or raised bone mineral density (BMD). Hence, bone quality plays an important role in the pathogenesis of skeletal fragility due to T2DM. This study analyzed the changes in the trabecular bone microstructure due to T2DM at various time points in ovariectomized and nonovariectomized rats. Animals were divided into four groups: (I) control (sham), (II) diabetic (sham), (III) ovariectomized, and (IV) ovariectomized with diabetes. The trabecular microarchitecture of the femoral head was characterized using a micro-CT. The differences between the groups were analyzed at 8, 10, and 14 weeks of the onset of T2DM using a two-way analysis of variance and by post hoc multiple comparisons. The diabetic group with and without ovariectomies demonstrated a significant increase in trabecular separation and a decrease in bone volume fraction, trabecular number, and thickness. BMD decreased in ovariectomized diabetic animals at 14 weeks of the onset of T2DM. No significant change was found in connectivity density and degree of anisotropy among groups. The structural model index suggested a change towards a weaker rod-like microstructure in diabetic animals. The data obtained suggested that T2DM affects the trabecular structure within a rat's femoral heads negatively and changes are most significant at a longer duration of T2DM, increasing the risk to hip fractures.
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