Evidence map›Paper›PMID 31815046›Full record

ArticleAmerican journal of cancer research2019

Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma.

Jia Yang, Su Hu, Junjie Shangguan, Aydin Eresen, Yu Li, Liang Pan, Quanhong Ma, Yuri Velichko, Jian Wang, Chunhong Hu and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Clinical translation of immunomodulatory therapeutics.Advanced drug delivery reviews · 2021
    Review
  5. Modeling pancreatic cancer in mice for experimental therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jia YangDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Su HuDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Junjie ShangguanDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Aydin EresenDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Yu LiDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Liang PanDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Quanhong MaDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Yuri VelichkoDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Jian WangDepartment of Radiology, Southwest Hospital Chongqing, China.
Chunhong HuDepartment of Radiology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu, China.
Vahid YaghmaiDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Zhuoli ZhangDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
First Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic CancerR01CA209886 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vahid Yaghmai, Zhuoli Zhang · 2016 to 2026
$3.3M
MRI-Guided Irreversible Electroporation Ablation for Liver TumorsR01CA196967 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, ZHUOLI · 2015 to 2018
$1.4M
NCI NIH HHS R01 CA196967NCI NIH HHS R01 CA209886
6 · The paper itself

Abstract

The promise of dendritic cell (DC)-based immunotherapy has been established by two decades of translational research. However, long-term benefits of DC vaccination are reported in only scattered patients with pancreatic ductal adenocarcinoma (PDAC). Here we optimize DC vaccination and evaluate its safety and antitumor efficacy in the genetically engineered PDAC model (

Indexed as

DC-based immunotherapymagnetic resonance imagingPancreatic ductal adenocarcinoma

Identifiers

PMID31815046
PMCPMC6895456
OpenAlexW3006799979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.