Evidence map›Paper›PMID 31815032›Full record

ArticleLiver research (Beijing, China)2018

Deficiency of pyruvate dehydrogenase kinase 4 sensitizes mouse liver to diethylnitrosamine and arsenic toxicity through inducing apoptosis.

Jonathan Choiniere, Matthew Junda Lin, Li Wang, Jianguo Wu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver research (Beijing, China), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Jonathan ChoiniereDepartment of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Matthew Junda LinDepartment of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Li WangDepartment of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Jianguo WuDepartment of Physiology and Neurobiology, Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
University of Connecticut · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
SHP-regulation of Lipid and Lipoprotein MetabolismR01DK080440 · NIDDK · UNIVERSITY OF UTAH · PI WANG, LI · 2008 to 2015
$2.3M
LncRNA as a New Mediator of Bile Acid HomeostasisR01DK104656 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2018
$1.7M
Molecular Basis of Cancer Cell Metabolic ReprogrammingR01ES025909 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2017
$1.0M
Long noncoding RNAs in alcoholic liver diseaseR21AA024935 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, WANG, LI · 2016 to 2017
$431k
Alcohol, nuclear receptor signaling, and circadian clocksR21AA022482 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2016
$415k
BLRD VA I01 BX002634NIAAA NIH HHS R21 AA022482NIAAA NIH HHS R21 AA024935NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK080440NIDDK NIH HHS R01 DK104656NIEHS NIH HHS R01 ES025909
6 · The paper itself

Abstract

BACKGROUND AND

aimPyruvate dehydrogenase kinase 4 (PDK4) is a metabolism switch that regulates glucose oxidation and the tricarboxylic acid cycle (TCA cycle) in the mitochondria. Liver detoxifies xenobiotics and is constantly challenged by various injuries. This study aims at understanding how the loss of the metabolism regulator PDK4 contributes to liver injuries.

methodsWild-type (WT) and

resultsWe showed that systematic

conclusionsPDK4 may contribute to the protection from apoptotic injury in mouse liver.

Indexed as

Cell deathHepatocytesLiver injuryPyruvate dehydrogenase kinase 4 (PDK4)

Identifiers

PMID31815032
PMCPMC6896988
OpenAlexW2801874091

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.