ArticleBDJ open2019
Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis.
Article in BDJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Adjunctive therapea - a promising method in the treatment of periodontal disease.Clinical oral investigations · 2025Trial
- Adjunctive Gaseous Ozone Improves Clinical and Microbiological Outcomes in Periodontitis: A Randomized Split-Mouth Study.Dentistry journal · 2026Article
- Probiotics and Ozonated Olive Oil to Maintain Oral Eubiosis in Stage I and II Periodontitis Patients: A Randomized Triple-Blind Clinical Trial.Dentistry journal · 2026Article
- Adjunctive Use of Ozone Therapy in Treating Periodontitis in Smokers: A Prospective Split-Mouth Study.International journal of dentistry · 2026Article
- Oxygen-Based Adjunct Therapies in Periodontitis: A Systematic Review and Meta-Analysis Within the Framework of Hypoxia and Inflammation.Biomedicines · 2025Review
- To Evaluate the Efficacy of Ozonated Olive Oil with Microneedling for Gingival Inflammation-A Clinical Study.Journal of pharmacy & bioallied sciences · 2025Article
- Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: A Randomized Double-Blind Trial.Journal of clinical medicine · 2025Article
- Effectiveness of Ozone Therapy in Non-Surgical Periodontal Treatment: A Meta-Analysis of Topical Applications.Journal of clinical medicine · 2025Review
- Evaluating Ozonated Olive Oil and Chlorhexidine Gel as a Therapeutic Intervention for Periodontitis Stage II Grade A.Cureus · 2025Article
- Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Effect of ozonated oil versus chlorhexidine gel among Indian patients with chronic periodontitis.Bioinformation · 2024Article
- Is Ozone a Valid Adjuvant Therapy for Periodontitis and Peri-Implantitis? A Systematic Review.Journal of personalized medicine · 2023Review
- Efficacy Ozone Therapy in Reducing Periodontal Disease.Materials (Basel, Switzerland) · 2023Article
- Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary Management of Peri-Implant Mucositis: A Randomized Clinical Trial.Journal of clinical medicine · 2023Article
- Effect of 20-ppm ozone and 1% chlorhexidine gels on plaque index andJournal of dental research, dental clinics, dental prospects · 2023Article
- Comparison of Ozonated Olive Oil and Chlorhexidine Gel as an Adjunct to Nonsurgical Periodontal Therapy for the Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial.Journal of pharmacy & bioallied sciences · 2022Article
- BDJ Open (2019-2020) and the advantages of open access publishing.British dental journal · 2021Article
- Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application.Biology · 2021Article
- Bio-Inspired Systems in Nonsurgical Periodontal Therapy to Reduce Contaminated Aerosol during COVID-19: A Comprehensive and Bibliometric Review.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScaling and root planning (SRP) is the gold standard approach for treatment of chronic periodontitis but used alone it may not be effective in removing periodontal pathogens from sites where access is poor.
objectiveTo evaluate and compare the clinical and microbiological efficacy of ozone and chlorhexidine (CHX) as an adjunct to SRP in patients with chronic periodontitis.
methodsTwenty-five patients with generalized moderate to severe chronic periodontitis with presence of at least one site in each quadrant with a probing depth ≥5 mm were recruited. In a split mouth study design, two quadrants were randomly allocated to the SRP and ozone therapy and the remaining two quadrants to SRP and CHX therapy. Plaque index (PI), Gingival index (GI), probing depth (PD), clinical attachment loss (CAL) were assessed. Subgingival plaque samples were obtained for assessment of
resultsBoth groups demonstrated significant intragroup reduction in PI, GI, PD, CAL, Pg count and Aa count from baseline to 3 months follow-up. There were no significant differences between two groups for any of the parameters.
conclusionOzonated olive oil can be used as an adjunctive subgingival irrigant in patients with chronic periodontitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.