ArticleMicrosystems & nanoengineering2019
Quantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes.
Article in Microsystems & nanoengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Microfluidic Chip Platforms for Red Blood Cell Storage Lesion Quality Control and Precision Transfusion.Research (Washington, D.C.) · 2026Review
- Live, spatially-resolved imaging of absolute intracellular water content using holotomography.Biomedical optics express · 2025Article
- Biophysical Profiling of Sickle Cell Disease Using Holographic Cytometry and Deep Learning.International journal of molecular sciences · 2023Article
- Rapid and precise tracking of water influx and efflux across cell membranes induced by a pulsed electric field.Biomedical optics express · 2023Article
- Multiscale optical phase fluctuations link disorder strength and fractal dimension of cell structure.Biophysical journal · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- White blood cell detection, classification and analysis using phase imaging with computational specificity (PICS).Scientific reports · 2022Article
- Single Cell RNA-Seq Analysis of Human Red Cells.Frontiers in physiology · 2022Article
- Single Cell Analysis of Stored Red Blood Cells Using Ultra-High Throughput Holographic Cytometry.Cells · 2021Article
- Label-free screening of brain tissue myelin content using phase imaging with computational specificity (PICS).APL photonics · 2021Article
- Repetitive optical coherence elastography measurements with blinking nanobombs.Biomedical optics express · 2020Article
- Spatial scanning of a sample with two-dimensional angle-resolved low-coherence interferometry for analysis of anisotropic scatterers.Biomedical optics express · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Changes in the deformability of red blood cells can reveal a range of pathologies. For example, cells which have been stored for transfusion are known to exhibit progressively impaired deformability. Thus, this aspect of red blood cells has been characterized previously using a range of techniques. In this paper, we show a novel approach for examining the biophysical response of the cells with quantitative phase imaging. Specifically, optical volume changes are observed as the cells transit restrictive channels of a microfluidic chip in a high refractive index medium. The optical volume changes indicate an increase of cell's internal density, ostensibly due to water displacement. Here, we characterize these changes over time for red blood cells from two subjects. By storage day 29, a significant decrease in the magnitude of optical volume change in response to mechanical stress was witnessed. The exchange of water with the environment due to mechanical stress is seen to modulate with storage time, suggesting a potential means for studying cell storage.
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Registered trials
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