ArticleAmerican journal of translational research2019
LncRNA PTCSC3 suppressed cervical carcinoma cell invasion and proliferation via regulating miR-574-5p.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- lncRNAs: a new generation of targets and biomarkers in thyroid cancer.European thyroid journal · 2026Review
- MiR-484 Regulates the IL-6/STAT3 Signaling Pathway by Down-Regulating KLF12 to Inhibit the Malignant Progression of Cervical Cancer.International journal of women's health · 2025Article
- miR-574-5p in epigenetic regulation and Toll-like receptor signaling.Cell communication and signaling : CCS · 2024Review
- Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues.Applied biochemistry and biotechnology · 2024Article
- Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues.Applied biochemistry and biotechnology · 2024Article
- Human bone marrow mesenchymal stem cell-driven LncRNA PTCSC3 upregulation within lung adenocarcinoma cells reduces erlotinib resistance by mitigating Wnt/β-Catenin pathway.American journal of cancer research · 2024Article
- A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders.Cancer cell international · 2023Review
- Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG.Oncology letters · 2023Article
- CTBP1-AS2 promoted non-small cell lung cancer progression via sponging the miR-623/MMP3 axis.Environmental science and pollution research international · 2022Article
- Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells.Molecular biology reports · 2022Article
- Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p.Experimental and therapeutic medicine · 2021Article
- hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p.Cell death discovery · 2021Article
- Role of the long non-coding RNA LINC00052 in tumors.Oncology letters · 2021Review
- LncRNA MALAT1 Accelerates Cervical Carcinoma Proliferation by Suppressing miR-124 Expression in Cervical Tumor Cells.Journal of oncology · 2021Article
- ELFN1-AS1 accelerates cell proliferation, invasion and migration via regulating miR-497-3p/CLDN4 axis in ovarian cancer.Bioengineered · 2020Article
- miR-378a-5p improved the prognosis and suppressed the progression of hepatocellular carcinoma by targeting the VEGF pathway.Translational cancer research · 2020Article
- The Search of miRNA Related to Invasive Growth of Nonfunctioning Gonadotropic Pituitary Tumors.International journal of endocrinology · 2020Article
- LncRNA PTCSC3 and lncRNA HULC Negatively Affect Each Other to Regulate Cancer Cell Invasion and Migration in Gastric Cancer.Cancer management and research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LncRNAs have been shown to invovled in the development of various cancers. However, the function and potential mechanism of PTCSC3 in cervical carcinoma progression remains unknown. In this reference, we showed that PTCSC3 expression was downregulated in 4 cervical carcinoma cell lines (Caski, Siha, Hela and C4-1) compared to control cell line (GH329). Expression of PTCSC3 was downregulated in cervical carcinoma samples compared to non-cancerous samples. Ectopic expression of PTCSC3 inhibited miR-574-5p expression and enhanced the expression of SCAI both in Hela cell and Siha cell. We proved that the miR-574-5p expression was overexpressed in 4 cervical carcinoma cell lines (Caski, Siha, Hela and C4-1) compared to control cell line (GH329). Expression of miR-574-5p was overexpressed in cervical carcinoma samples compared to non-cancerous samples. Furthermore, we indicated that expression of miR-574-5p was negatively correlated with expression of PTCSC3 in cervical carcinoma. Ectopic expression of PTCSC3 decreased cell proliferation and invasion. Finally, we indicated that PTCSC3 overexpression suppressed cervical carcinoma progression via regulating miR-574-5p expression. These data suggested that PTCSC3 played as an oncogene in progression of cervical carcinoma.
Indexed as
Identifiers
31814920PMC6895514W2997714895What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.