ArticleAmerican journal of translational research2019
The effects of local injection of exosomes derived from BMSCs on random skin flap in rats.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Bone marrow mesenchymal stem cell exosomes in osteonecrosis: pathological mechanisms and therapeutic strategies.Molecular biology reports · 2026Review
- Exosome therapy for flap and skin graft survival: A systematic review and meta-analysis of preclinical evidence.JPRAS open · 2026Review
- Applications of extracellular vesicles in tissue regeneration: a narrative review.Frontiers in bioengineering and biotechnology · 2026Review
- Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival.Clinical and translational medicine · 2026Article
- Exosomes in Skin Flap Survival: Unlocking Their Role in Angiogenesis and Tissue Regeneration.Biomedicines · 2025Review
- Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches.Molecular therapy. Nucleic acids · 2023Review
- Hypoxia in Skin Cancer: Molecular Basis and Clinical Implications.International journal of molecular sciences · 2023Review
- Exosomes as Intercellular Messengers in Hypertension.International journal of molecular sciences · 2021Review
- Preclinical Experimental Applications of miRNA Loaded BMSC Extracellular Vesicles.Stem cell reviews and reports · 2021Review
- Tissue Regeneration Capacity of Extracellular Vesicles Isolated From Bone Marrow-Derived and Adipose-Derived Mesenchymal Stromal/Stem Cells.Frontiers in cell and developmental biology · 2021Review
- Advances on Graphene-Based Nanomaterials and Mesenchymal Stem Cell-Derived Exosomes Applied in Cutaneous Wound Healing.International journal of nanomedicine · 2021Review
- Exosomes and Their Role in Cancer Progression.Frontiers in oncology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine if the viability of random pattern dorsal skin flaps in rats could be improved with local injection of exosomes derived from bone marrow mesenchymal stem cells (BMSCs).
methods30 adult male SD rats (weight 200-250 g) were randomly divided into experimental and control groups. Exosomes were isolated from the 4th generation of BMSCs. Experimental group were treated with local injection of exosomes suspension while control group were treated with saline solution in the same way. McFarlane-type flaps (9.0 × 3.0 cm) were then operated in the dorsum of all. On the seventh postoperative day, the percentage of viability area was measured and the blood flow was detected by laser doppler. Then rats were sacrificed and flaps were cut off for further check.
resultsCompared with controls, the exosomes increased the area of survival (P<0.05). Hematoxylin and eosin (HE) staining of zone II showed higher microvascular density (P<0.05) and better angiogenesis (P<0.05) in the exosomes group. Similarly, the blood flow of exosomes was better than the control group according to laser doppler imaging (P<0.05). And the result of immunohistochemistry and western blot showed that the exosomes group had significantly higher VEGF and CD34 expression compared to the controls (P<0.05).
conclusionsLocal injection of BMSCs exosomes was effective to attenuate necrosis of the McFarlane-type flaps in rats.
Indexed as
Identifiers
31814909PMC6895502W2996337333What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.