ArticleAmerican journal of translational research2019
Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-κB/NLRP3 signaling pathway.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Dietary Quercetin-3-Glucuronide Mitigates Oxidative Stress, Inflammation, and Fibroblast Transition by Regulating Nrf2 and Autophagy in Pulmonary Fibrosis.Journal of agricultural and food chemistry · 2026Article
- Qingwen Hufei Granules Attenuate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing NLRP3 Inflammasome-Dependent Pyroptosis.Journal of inflammation research · 2025Article
- Mass spectrometry-based metabolomics reveal the effects and potential mechanism of isochlorogenic acid A in MC3T3-E1 cells.Frontiers in molecular biosciences · 2025Article
- Lead-induced liver fibrosis and inflammation in mice by the AMPK/MAPKs/NF-κB and STAT3/TGF-β1/Smad2/3 pathways: the role of Isochlorogenic acid a.Toxicology research · 2024Article
- In vitro and in vivo protective potential of quercetin-3-glucuronide against lipopolysaccharide-induced pulmonary injury through dual activation of nuclear factor-erythroid 2 related factor 2 and autophagy.Archives of toxicology · 2024Article
- Pharmacological profile of dicaffeoylquinic acids and their role in the treatment of respiratory diseases.Frontiers in pharmacology · 2024Review
- Acute Lung Injury and the NLRP3 Inflammasome.Journal of inflammation research · 2024Review
- The inhibitory effect of quercetin-3-glucuronide on pulmonary injury in vitro and in vivo.Journal of food and drug analysis · 2023Article
- Dietary Stevia Residue Extract Supplementation Improves Antioxidant Capacity and Intestinal Microbial Composition of Weaned Piglets.Antioxidants (Basel, Switzerland) · 2022Article
- Rutaecarpine ameliorates lipopolysaccharide-induced BEAS-2B cell injury through inhibition of endoplasmic reticulum stress via activation of the AMPK/SIRT1 signaling pathway.Experimental and therapeutic medicine · 2022Article
- Polyphenols in Ilex latifolia Thunb. inhibit human lung cancer cell line A549 by regulation of the PI3K-Akt signaling pathway.BMC complementary medicine and therapies · 2022Article
- Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus.Acta pharmaceutica Sinica. B · 2022Article
- Fengreqing Oral Liquid Exerts Anti-Inflammatory Effects by Promoting Apoptosis and Inhibiting PI3K/AKT and NF-κB Signaling Pathways.Frontiers in pharmacology · 2022Article
- MicroRNA-490-3p inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats by suppressing the IRAK1/TRAF6 pathway.Experimental and therapeutic medicine · 2021Article
- miR‑26a‑5p alleviates lipopolysaccharide‑induced acute lung injury by targeting the connective tissue growth factor.Molecular medicine reports · 2021Article
- Network Pharmacology-Based Identification of Potential Targets ofBioMed research international · 2021Article
- Agnuside Alleviates Synovitis and Fibrosis in Knee Osteoarthritis through the Inhibition of HIF-1Mediators of inflammation · 2021Article
- Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS.Pharmaceutical biology · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, there is still no effective drug with small side effects for acute lung injury. Monomer of herb is promising for anti-inflammation therapy. In this study, we first investigated the possible effects of isochlorogenic acid A in acute lung injury induced by LPS. The effects of oxidant stress, pulmonary edema and inflammation factors induced by LPS were inhibited by isochlorogenic acid A. Levels of lung active markers and inflammation factors induced by LPS were reversed by isochlorogenic acid A. Isochlorogenic acid A inhibited the cell apoptosis induced by LPS. The protein expressions of Nf-κB/NLRP3 signaling pathway induced by LPS were inhibited by isochlorogenic acid A. In summary, isochlorogenic acid A reversed the effects induced by LPS in acute lung injury and is a promising monomer for therapy of acute lung injury, providing references for future research on therapy of acute lung injury.
Indexed as
Identifiers
31814905PMC6895519W2997122526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.