ArticleAmerican journal of translational research2019
miR-1 and miR-802 regulate mesenchymal-epithelial transition during kidney development by regulating Wnt-4/β-catenin signaling.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- miR-802-5p is a key regulator in diabetic kidney disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- MiR-107 Regulates Adipocyte Differentiation and Adipogenesis by Targeting Apolipoprotein C-2 (Genes · 2022Article
- Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.Oxidative medicine and cellular longevity · 2020Article
- Bioinformatic Investigation of Micro RNA-802 Target Genes, Protein Networks, and Its Potential Prognostic Value in Breast Cancer.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMesenchymal-epithelial transition (MET) is an important part of kidney development. However, the role of microRNA (miRNA) in MET and the regulating mechanism is still not well known. MATERIALS AND
methodsqRT-PCR and western blot were performed to detect the expression of miR-1 and miR-802 and related protein expression. Luciferase reporter assay and western blot were used to identify the target of miR-1 and miR-802. Confocal microscopy was used to analyze the MET process.
resultsWe demonstrated that miR-1 expression was downregulated and miR-802 expression was upregulated during kidney development. And during the process, proteins levels of Wnt-4 and β-catenin changed significantly. In MDCK cells, overexpression of Wnt-4 inhibited the expression of β-catenin, and promote the MET, and overexpression of β-catenin inhibited MET. Further studies suggested that miR-1 and miR-802 regulated MET by binding to Wnt-4 and β-catenin mRNA, regulated the expression of Wnt-4 and β-catenin. In conclusion, miR-1 and miR-802 regulate MET during kidney development by regulating Wnt-4/β-catenin signaling.
Indexed as
Identifiers
31814903PMC6895509What OpenQuestion holds
Registered trials
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