Evidence map›Paper›PMID 31814896›Full record

ArticleAmerican journal of translational research2019

Multiplexed detection and the establishment of a novel high-throughput method for human germ cell quality screening based on aggregation-induced emission.

Zixuan Zeng, Xiaojiao Ren, Tailang Yin, Xiang Gao, Mengting Tsai, Yi Zhang, Meijia Gu

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zixuan ZengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University Wuhan 430071, Hubei, China.
Xiaojiao RenKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University Wuhan 430071, Hubei, China.
Tailang YinReproductive Medicine Center, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.
Xiang GaoReproductive Medicine Center, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.
Mengting TsaiKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University Wuhan 430071, Hubei, China.
Yi ZhangKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University Wuhan 430071, Hubei, China.
Meijia GuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University Wuhan 430071, Hubei, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rapid, sensitive, and high-throughput method for quality control of human sperm cells and oocytes staining based on the aggregation-induced emission feature of the tetraphenylethylene-based luminogen (TPE-Ph-In), which is mitochondria-specific. Germ cells are evaluated to assess fertility and to facilitate assisted reproduction. In regular clinical practice, sperm quality is determined on the basis of visual examination and mathematical models of the sperm cell number, motility, and morphology. The maturation of the oocyte is crucial for the developmental competence of the resulting embryo. Human

Indexed as

Aggregation-induced emission (AIE)human germ cell qualitytetraphenylethylene (TPE)

Identifiers

PMID31814896
PMCPMC6895534
OpenAlexW2996431963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.